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Dual delivery of hydrophilic and hydrophobic drugs from chitosan/diatomaceous e...

López-Cebral, Rita; Peng, Guangjia; Reys, Lara L.; Silva, Simone Santos; Oliveira, Joaquim M.; Chen, Jie; Silva, Tiago José Quinteiros Lopes Henriques

Oral administration of drugs presents important limitations, which are frequently not granted the importance that they really have. For instance, hepatic metabolism means an important drug loss, while some patients have their ability to swell highly compromised (i.e. unconsciousness, cancer...). Sublingual placement of an accurate Pharmaceutical Dosage Form is an attractive alternative. This work explores the u...


Preparation and characteristics of the sulfonated chitosan derivatives electrod...

Huang, Ye; Peng, Guangjia; Chen, Bin; Yong, Ping; Yao, Nan; Yang, Liming; Pirraco, Rogério P.; Reis, R. L.; Chen, Jie

In order to ameliorate the properties of corrosion resistance and achieve applications in anti-biofouling of 316L stainless steel (SS), a sulfated derivative of chitosan was deposited onto stainless steel surface by an electrochemical method. In detail, chitosan-catechol (CS-CT) was synthesised in the hydrochloric acid solution by the Mannich reaction and then electrodeposited on the surface of the polished 316...


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