106 documents found, page 1 of 11
Development and in vitro assessment of injectable, adhesive, and self-healing c...
Correia, Cátia Sofia Palma; Peixoto, D.; Soares da Costa, Diana; Reis, R. L.; Pashkuleva, I.; Alves, N. M.Injured spinal cords have a limited ability to regenerate because of the inhibitory environment formed in situ that affects neuronal regrow. Ensuring stable contact between the injuried nerves to support neural regeneration in the lesion microenvironment remains a significant challenge. To address this challenge, we have engineered a new injectable and adhesive hydrogel to treat spinal cord injuries. This hydro...
Effect of hyaluronan molecular weight on the stability and biofunctionality of ...
Albuquerque, A. V.; Soares da Costa, D.; Correia, Cátia Sofia Palma; Reis, R. L.; Alves, N. M.; Costa, Rui Filipe Ramos; Pashkuleva, I.Nervous system disorders are characterized by a progressive loss of function and structure of neurons that ultimately leads to a decline in cognitive and motor functions. In this study, we used interfacial polyelectrolyte complexation (IPC) to produce fibers for neural tissue regeneration. IPC is a processing method that allows spinning of sensitive biopolymers. The rate of spinning and the properties of the us...
Biomateriais e Medicina Regenerativa: o papel do I3Bs numa estratégia de susten...
Silva, Tiago H.; Almeida, Mariana; Peixoto, Daniela; Fernandes, Emanuel Mouta; Alves, N. M.; Reis, R. L.[Excerto] O Instituto de Investigação em Biomateriais, Biodegradáveis e Biomiméticos, I3Bs, é a mais recente Unidade Orgânica da Universidade do Minho, surgindo em março de 2018, tendo sido uma das primeiras Unidades Orgânicas de Investigação criada no âmbito do RJIES (2007) em Universidades públicas Portuguesas. No entanto, a sua história tem origem em 1999, com a criação do Grupo de Investigação 3B’s, dedicad...
Multifunctional calcium-based nanocarriers for synergistic treatment of triple-...
Martins, Sara A.; Costa, Rui R.; Brito, Alexandra; Reis, R. L.; Alves, N. M.; Pashkuleva, I.; Soares da Costa, DianaTargeted breast cancer therapies hold the potential to improve the efficiency of drug delivery to the pathology site without impacting the viability and function of healthy cells. Herein, we developed multifunctional nanocarriers that target simultaneously several downstream signaling processes in triple negative breast cancer cells. The system comprises pH sensitive CaCO3 nanoparticles (NPs) as carriers of the...
Antibacterial properties of photo-crosslinked chitosan/methacrylated hyaluronic...
Gonçalves, Raquel R.; Peixoto, Daniela; Costa, Rui R.; Franco, Albina Ribeiro; Castro, Vânia I. B.; Pires, R. A.; Reis, R. L.; Pashkuleva, I.The current treatments for wounds often fail to produce adequate healing, leaving wounds vulnerable to persistent infections and development of drug-resistant microbial biofilms. New natural-derived nanoparticles were studied to impair bacteria colonization and hinder the formation of biofilms in wounds. The nanoparticles were fabricated through polyelectrolyte complexation of chitosan (CS, polycation) and hyal...
Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury
Duarte, Diogo; Correia, Cátia; Reis, R. L.; Pashkuleva, I.; Peixoto, Daniela; Alves, N. M.Spinal cord injuries (SCI) have devastating physical, psychological, and psycho-social consequences for patients. One challenge of nerve tissue repair is the lack of a natural extracellular matrix (ECM) that guides the regenerating axons. Hyaluronic acid (HA) is a major ECM component and plays a fundamental role in facilitating lesion healing. Herein, we developed HA-based adhesive hydrogels by modification of ...
Layer-by-layer coated calcium carbonate nanoparticles for targeting breast canc...
Bastos, F. R.; Soares da Costa, Diana; Reis, R. L.; Alves, N. M.; Pashkuleva, I.; Costa, Rui Filipe RamosBreast cancer is resistant to conventional treatments due to the specific tumour microenvironment, the associated acidic pH and the overexpression of receptors that enhance cells tumorigenicity. Herein, we optimized the synthesis of acidic resorbable calcium carbonate (CaCO3) nanoparticles and the encapsulation of a low molecular weight model molecule (Rhodamine). The addition of ethylene glycol during the synt...
Hyaluronan functionalized pH-responsive calcium carbonate nanoparticles for loc...
Bastos, F. R.; Costa, R. R.; Soares da Costa, Diana; Reis, R. L.; Pashkuleva, I.; Alves, N. M.[Excerpt] Introduction: Current radio- and chemotherapies are not efficient and many tumors remain resistant to conventional cancer treatments. Specific properties and signaling molecules from tumor microenvironment (TME) have been explored to increase treatment efficacy. An example is the acidic pH of the TME that has been explored to develop stimuli responsive release systems. Herein, we obtained biocompatibl...
Biocompatible 3D-printed tendon/ligament scaffolds based on polylactic acid/gra...
Silva, Magda Sofia Gonçalves; Gomes, Susana; Correia, Cátia Sofia Palma; Peixoto, Daniela; Vinhas, Carla Adriana Araújo; Rodrigues, Márcia T.Three-dimensional (3D) printing technology has become a popular tool to produce complex structures. It has great potential in the regenerative medicine field to produce customizable and reproducible scaffolds with high control of dimensions and porosity. This study was focused on the investigation of new biocompatible and biodegradable 3D-printed scaffolds with suitable mechanical properties to assist tendon an...
Exploiting polyelectrolyte complexation for the development of adhesive and bio...
Fonseca, Mário C.; Vale, A. Catarina; Costa, Rui R.; Reis, R. L.; Alves, N. M.Mussels secrete protein-based byssal threads to tether to rocks, ships, and other organisms underwater. The secreted marine mussel adhesive proteins (MAPs) contain the peculiar amino acid L-3,4-dihydroxyphenylalanine (DOPA), whose catechol group content contributes greatly to their outstanding adhesive properties. Inspired by such mussel bioadhesion, we demonstrate that catechol-modified polysaccharides can be ...