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Insights into circulating CEACAM1 in insulin clearance and disease progression
Patarrão, Rita S.; Meneses, Maria João; Ghadieh, Hilda E.; Herrera, Laura; Duarte, Sérgio; Ribeiro, Rogério T.; Raposo, João F.; Schmitt, VerenaFunding Information: The authors thank the study participants for commitment and loyalty. The authors would like to acknowledge the guidance of the late PD Dr. Bernhard B. Singer, PhD and from Verena Schmitt, PhD from the Universit\u00E4tsklinikum, Essen, Germany for their guidance on setting up the ELISA analysis of circulating CEACAM1 levels. This study was supported by \u201CFunda\u00E7\u00E3o para a Ci\u00E...
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reve...
Ribeiro, Andreia Fiúza; Fitas, Ana Laura; Pires, Marcela Oliveira; Matoso, Paula; Ligeiro, Dário; Sobral, Daniel; Penha-Gonçalves, CarlosPublisher Copyright: Copyright © 2024 Andreia Fiúza Ribeiro et al.; Aims: This study is aimed at comparing whole exome sequencing (WES) data with the clinical presentation in children with type 1 diabetes onset ≤ 5 years of age (EOT1D). Methods: WES was performed in 99 unrelated children with EOT1D with subsequent analysis to identify potentially deleterious rare variants in MODY genes. High-resolution HLA clas...
The rare DRB1*04:08-DQ8 haplotype is the main HLA class II genetic driver and d...
Caramalho, Iris; Matoso, Paula; Ligeiro, Dário; Paixão, Tiago; Sobral, Daniel; Fitas, Ana Laura; Limbert, Catarina; Demengeot, JocelyneFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the European Foundation for the Study of Diabetes (EFSD/JDRF/Lilly Programme 2016), Maratona da Saúde and Fundação para a Ciência e a Tecnologia (CEECIND/00148/2017 to Iris Caramalho). Acknowledgments Publisher Copyright: Copyright © 2024 Caramalh...
Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin s...
Patarrão, Rita S.; Duarte, Nádia; Coelho, Inês; Ward, Joey; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Costa, João; Correia, IsabelFunding Information: The PREVADIAB-2 study was supported by a grant from the Portuguese Directorate General of Health. This work was financed by Fundação para a Ciência e Tecnologia (reference number PTDC/BIM/MET/4265/2014), by iNOVA4Health UIDB/Multi/04462/2020 and by ONEIDA (project E-411021.01, Lisboa-01-0145-FEDER-016417, co-funded by FEEI [Fundos Europeus Estruturais e de Investimento] from Programa Operac...
Individual variation in susceptibility or exposure to SARS-CoV-2 lowers the her...
Gomes, M. Gabriela M.; Ferreira, Marcelo Urbano; Corder, Rodrigo M.; King, Jessica G.; Souto-Maior, Caetano; Penha-Gonçalves, CarlosFunding Information: We thank Jorge Carneiro, Ben Cooper, José Ferreira Machado, Kate Langwig, Robert MacKay, Paul McKeigue, Antonio Montalbán, Joe Schoneman, Laurette Tuckerman and Simon Wood for valuable discussions throughout this study. At the University of Strathclyde, Matthew Burns, Zhichun Jiang, Naithan McNeil, Lauren Schofield and Aidan West conducted their final year BSc projects on Communicating Math...
Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells Duri...
Coelho, Inês; Duarte, Nádia; Barros, André; Macedo, Maria Paula; Penha-Gonçalves, CarlosThis work was developed with the support of the research infrastructure Congento, project LISBOA-01-0145-FEDER022170, co-financed by Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and FCT – “Fundação para a Ciência e a Tecnologia” (Portugal). This work was partially supported by ONEIDA project (LISBOA-0...
Insights into Macrophage/Monocyte-Endothelial Cell Crosstalk in the Liver
Coelho, Inês; Duarte, Nádia; Macedo, Maria Paula; Penha-Gonçalves, CarlosFunding: This work was funded with the support of Ferring innovation grant 2019 from Ferring Research Institute, Gilead Genese 2019 from Gilead Sciences Lda, “Fundação para a Ciência e Tecnologia” (PTDC/MEC447 MET/29314/2017) and iNOVA4Health (UIDB/Multi/04462/2020).; Liver disease accounts for millions of deaths worldwide annually being a major cause of global morbidity. Hepatotoxic insults elicit a multilayer...
Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Dama...
Duarte, Nádia; Coelho, Inês; Holovanchuk, Denys; Inês Almeida, Joana; Penha-Gonçalves, Carlos; Paula Macedo, MariaDipeptidyl peptidase-4 (DPP-4 or clusters of differentiation [CD]26) is a multifunctional molecule with established roles in metabolism. Pharmacologic inhibition of DPP-4 is widely used to improve glycemic control through regulation of the incretin effect. Colaterally, CD26/DPP-4 inhibition appears to be beneficial in many inflammatory conditions, namely in delaying progression of liver pathology. Nevertheless,...
inTB - a data integration platform for molecular and clinical epidemiological a...
Soares, Patrícia; Alves, Renato J.; Abecasis, Ana; Penha-Gonçalves, Carlos; Gomes, M. Gabriela M; Pereira-Leal, José B.BACKGROUND Tuberculosis is currently the second highest cause of death from infectious diseases worldwide. The emergence of multi and extensive drug resistance is threatening to make tuberculosis incurable. There is growing evidence that the genetic diversity of Mycobacterium tuberculosis may have important clinical consequences. Therefore, combining genetic, clinical and socio-demographic data is critical to u...