7 documents found, page 1 of 1
Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sar...
Martinho, Olga; Campos, Marcelo [UNESP]; Ribeiro, Guilherme; Penna, Valter; Curcelli, Emílio C. [UNESP]; Olivieri, Marcus V.; Morini, SandraMade available in DSpace on 2018-12-11T17:00:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-01; Objective: Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf ki...
Centrosome amplification in chondrosarcomas: A primary cell culture and cryopre...
Pinheiro, Carla Aparecida; Soares, Iberê Cauduro; Penna, Valter; Squire, Jeremy; Reis, R. M.; Silva, Sandra Regina Morini da; Carvalho, Isabela deThe genetics background underlying the aggressiveness of chondrosarcoma (CS) is poorly understood. One possible cause of malignant transformation is chromosomal instability, which involves an error in mitotic segregation due to numerical and/or functional abnormalities of centrosomes. The present study aimed to evaluate centrosome amplification in cryopreserved samples of tumor tissue from patients with CS. An ...
Raf kinase inhibitor protein expression and prognostic value in soft tissue sar...
Martinho, Olga; Campos, Marcelo; Ribeiro, Guilherme; Penna, Valter; Curcelli, Emílio C.; Olivieri, Marcus V.; Morini, Sandra; Scapulatempo, CristovamObjective: Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated with prognosis in several human neoplasms; however, its rol...
Absence of microsatellite instability in soft tissue sarcomas
Campanella, Nathália C.; Penna, Valter; Ribeiro, Guilherme; Abrahão-Machado, Lucas Faria; Scapulatempo-Neto, Cristovam; Reis, R. M.Here, we analyze a series of soft tissue sarcomas (STS), which are a heterogeneous group of mesenchymal neoplasms, for the presence and frequency of microsatellite instability (MSI). MSI has been proposed to be clinically relevant for colorectal cancer, yet on STS its role is not consensual, partly due to the limited number of cases analyzed and methodology issues.
Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...
Pinheiro, Céline; Penna, Valter; Santos, Filipa Morais; Abrahão-Machado, Lucas Faria; Ribeiro, Guilherme; Curcelli, Emílio C.; Olivieri, Marcus V.Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and therapeutic response. As highly glycolytic tumors, we hypothesized that sarcomas should present an increased expression of lactate transporters (M...
Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...
Pinheiro, Celine; Penna, Valter; Morais-Santos, Filipa; Abrahao-Machado, Lucas F.; Ribeiro, Guilherme; Curcelli, Emilio Carlos [UNESP]Made available in DSpace on 2014-12-03T13:08:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-05-09Bitstream added on 2014-12-03T13:23:21Z : No. of bitstreams: 1 WOS000336931400001.pdf: 1483231 bytes, checksum: d44026d999cd265cc444aeb241af66a4 (MD5); FCT (Portuguese Foundation for Science and Technology); FCT; Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current ther...
Ki-67 and CD100 immunohistochemical expression is associated with local recurre...
Campos, Marcelo; Campos, Sivana Gisele Pegorin de; Ribeiro, Guilherme Gomes; Eguchi, Flávia Coltri; Silva, Sandra Regina Morini daSoft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during diagnosis and the...