2 documents found, page 1 of 1
Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacab...
Freitas, Larissa De [UNESP]; Valli, Marilia [UNESP]; Dametto, Alessandra C. [UNESP]; Pennacchi, Paula C.; Andricopulo, Adriano D.Made available in DSpace on 2020-12-12T01:59:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; A bioassay-guided study aiming at identifying inhibitors of the glycation process on the leaves of Ocotea paranapiacabensis afforded four benzylisoquinoline alkaloids (1-4), with 1 and 2 identified as new naturals products, while 3 and 4 were previously described in the literature, with 3 being identifi...
MMP-9/RECK imbalance: a mechanism associated with high-grade cervical lesions a...
Discacciati, Michelle G.; Gimenes, Fabrícia; Pennacchi, Paula C.; Flores, Fernanda Faião; Zeferino, Luiz C.; Derchain, Sophie M.; Teixeira, Júlio C.BACKGROUND: Matrix metalloproteinases (MMP) are important enzymes in the tumor microenvironment associated with progression of cervical intraepithelial neoplasia (CIN) toward squamous cell carcinoma (SCC) of the cervix. However, the role of MMPs in the inflammatory process associated with Chlamydia trachomatis infection concomitant with the carcinogenic process driven by HPV has not yet been addressed. In the p...