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Effects of positive airway pressure therapy on cardiovascular and metabolic mar...

Feliciano, A.; Oliveira, M.J.; Cysneiros, A.; Martinho, C.; Reis, R.P.; Penque, D.; Pinto, P.; Bárbara, C.

Introduction: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular/ metabolic complications. Some analytical parameters (homocysteine, glycemic and lipidic profiles) are recognized markers of these consequences. Limited data is available on the association of these markers and OSAS’s severity/response to positive airway pressure therapy (PAP). Material and methods: In this prospective study...


Hematological evaluation in males with obstructive sleep apnea before and after...

Feliciano, A.; Linhas, R.; Marçôa, R.; Cysneiros, A.; Martinho, C.; Reis, R. P.; Penque, D.; Pinto, P.; Bárbara, C.

Obstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive...


Ceruloplasmin expression by human peripheral blood lymphocytes: a new link betw...

Banha, J.; Marques, L.; Oliveira, R.; Martins, M. de F.; Paixão, E.; Pereira, D.; Malhó, R.; Penque, D.; Costa, L.

Ceruloplasmin (CP) is a multicopper oxidase involved in the acute phase reaction to stress. Although the physiological role of CP is uncertain, its role in iron (Fe) homeostasis and protection against free radical-initiated cell injury has been widely documented. Previous studies showed the existence of two molecular isoforms of CP: secreted CP (sCP) and a membrane glycosylphosphatidylinositol (GPI)-anchored fo...


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