90 documents found, page 1 of 9
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osório, Hugo; Antunes, Marilia; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) is characterized by recurrent-episodes of apneas/hypopneas during sleep, leading to recurrent intermittent-hypoxia and sleep fragmentation. Non-treated OSA can result in cardiometabolic diseases. In this study, we applied a shotgun-proteomics strategy to deeper investigate the red blood cell-(RBC) homeostasis regulation in the context of OSA-severity and their response to six month...
Impacto do fumo do cigarro passivo no proteoma humano: em busca de biomarcadore...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Valentim-Coelho, Cristina; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahOs não-fumadores expostos ao fumo do cigarro passivo ou, simplesmente fumo passivo (FP), apresentam um risco acrescido de desenvolver diversas doenças graves. No entanto, os mecanismos moleculares que explicam estes efeitos continuam pouco esclarecidos, o que reforça a necessidade de identificar biomarcadores capazes de avaliar o risco associado a esta exposição. Neste estudo, analisámos o proteoma do epitélio ...
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osorio, Hugo; Antunes, Marília; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahFunding Information: Project partially supported by Harvard Medical School \u2013 Portugal Program ( HMSPICJ/0022/2011 ), Instituto Nacional de Sa\u00FAde Dr. Ricardo Jorge \u2013 INSA, Centro de Toxicogen\u00F3mica e Sa\u00FAde Humana \u2013 ToxOmics, Rede Nacional de Espectrometria de Massa \u2013 RNEM, FCT /Poly-Annual Funding Program and FEDER /Sa\u00FAde XXI Program, Portugal. Cristina Coelho (SFRH/BD/1335...
Second-hand smoke exposure modulates plasma proteins linked to detoxification, ...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Valentim-Coelho, Cristina; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahFunding Information: This work was supported by the Calouste Gulbenkian Foundation, Rede Nacional de Espectrometria de Massa (RNEM), National Institute of Health Doctor Ricardo Jorge, and UID/04923 - Comprehensive Health Research Centre.Sofia Neves (SFRH/BD/82648/2011), Solange A. Pacheco (SFRH/BD/74857/2010), Cristina Valentim-Coelho (SFRH/BD/133511/2017) and Joana Saraiva (2022.14435.BD) were granted with PhD...
Acute Venous Thromboembolism Plasma and Red Blood Cell Metabolomic Profiling Re...
Febra, Claudia; Saraiva, Joana; Vaz, Fátima; Macedo, João; Al-Hroub, Hamza Mohammad; Semreen, Mohammad Harb; Maio, Rui; Gil, Vitor; Soares, NelsonBackground: Venous thromboembolism(VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is still based on complex imaging exams due to the lack of biomarkers. Moreover, studies assessing the diagnostic capacity of novel metabolomics biomarkers in VTE are scarce. Our aim was to determine whether patients with acute VTE have differences in the metabolomic profile from plasma and red blo...
Occupational second-hand smoke exposure: A comparative shotgun proteomics study...
Neves, Sofia; Pacheco, Solange; Vaz, Fátima; James, Peter; Simões, Tânia; Penque, DeborahNon-smokers exposed to second-hand smoke (SHS) present risk of developing tobacco smoke-associated pathologies. To investigate the airway molecular response to SHS exposure that could be used in health risk assessment, comparative shotgun proteomics was performed on nasal epithelium from a group of healthy restaurant workers, non-smokers (never and former) exposed and not exposed to SHS in the workplace. HIF1α-...
Predictive Value for Increased Red Blood Cell Distribution Width in Unprovoked ...
Febra, Cláudia; Spinu, Verónica; Ferreira, Filipa; Gil, Victor; Maio, Rui; Penque, Deborah; Macedo, AnaAcute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic features of unprovoked VTE, early identification is challenging and has direct consequences on correct treatment delay. Longitudinal, prospective, observational stud...
Predictive value for increased red blood cell distribution width in unprovoked ...
Febra, Cláudia; Spinu, Verónica; Ferreira, Filipa; Gil, Victor; Maio, Rui; Penque, Deborah; Macedo, AnaAcute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic features of unprovoked VTE, early identification is challenging and has direct consequences on correct treatment delay. Longitudinal, prospective, observational stud...
Occupational secondhand smoke exposure may modify the proteoma expression of hu...
Neves, Sofia; Pacheco, Solange; Vaz, Fátima; Martins, Inês; James, Peter; Simões, Tânia; Penque, DeborahThe tobacco is one of the biggest public health threats, smoking kills more than 7 million people/year worldwide and more than 890,000 are deaths resulting from exposure to Second Hand Smoke (SHS). In adults, SHS is associated to cardiovascular and respiratory diseases, including coronary heart disease and lung cancer, through pathological and molecular mechanisms not yet understood. In this study, we aimed to ...
Shotgun proteomics of red blood cells from obstructive sleep apnea patients und...
Coelho, Cristina Valentim; Osório, Hugo; Vaz, Fatima; Neves, Sofia; Pinto, Paula; Barbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) syndrome is characterized by recurrent episodes of apneas and hypopneas during sleep, leading to recurrent intermittent hypoxia and sleep fragmentation. No treated OSA can result in metabolic and cardiovascular diseases. By 2D gel-based proteomics approach we have demonstrated that OSA can cause alterations in the red blood cells (RBC) proteome that may be associated with OSA outco...