7 documents found, page 1 of 1
Antimalarial potential of quinones isolated from plants: an integrative review
Gomes, Antonio Rafael Quadros; Brígido, Heliton Patrick Cordovil; Vale, Valdicley Vieira; Correa-Barbosa, Juliana; Percário, SandroAntimalarial treatment is often associated with the resistance developed by Plasmodium which generate ineffective drug treatment. Based on this, the search for therapeutic alternatives is necessary and urgent. This review intends to assess the antimalarial potential of quinones isolated from plants. The search for scientific articles was carried out on the CAPES Journal Portal (PPC), Virtual Health Library (VHL...
Pharmacological activities and their relationship with the oxidative stress of ...
Gomes-Sousa, Nathália Cássia; Nunes, Lucas dos Santos; Martins, Hanna Patrícia dos Santos; Percário, Sandro; Dolabela, Maria FâniThe present work made an analysis of pharmacological studies of Morinda citrifolia L. and the role of oxidative stress. The research was carried out on the Capes and PubMed Journals Portal. Initially, titles, abstracts were read and those that had no relation to the topic and in duplicate were excluded. After this process, the works were read in full and the information was extracted. A total of 517 articles we...
The relevance of implementing a Reference Center on Diabetic Foot in Marabá-PA,...
Beckemkamp, Tatiana Teixeira de Castro Carvalho; Percário, SandroObjective: Demonstrating the importance of the creation of Marabá Diabetic Foot Reference Center (CRPDM in Portuguese) for the city and region. Methodology: This is a cross-sectional, observational, retrospective study conducted at a general hospital in the city of Marabá-PA, Brazil. The study population is consisted of patients treated by the Vascular Surgery Department at the Hospital Municipal de Marabá, fro...
Anti-malarial activity and toxicity of Aspidosperma nitidum Benth: a plant used...
Brandão, Dayse Lucia do Nascimento; Martins, Michel Tavares; Silva, Adreanne Oliveira; Almeida, Amanda Dias; Paula, Renata Cristina deThe objective of this work was to evaluate the antiplasmodial activity and toxicity of the extract and fractions obtained from the bark of Aspidosperma nitidum. The ethanol extract obtained from the powdered bark of plants was acid-base partitioned and phytochemically analyzed. The antiplasmodial activity, in vivo antimalarial activity and in vitro cytotoxicity were acessed. The selectivity index (SI) was calcu...
Antitumor activity of Apocynaceae species used in Amazon traditional medicine
Bastos, Mirian Letícia Carmo; Sarmento, Rosana Moura; Bahia, Marcelo de Oliveira; Rodrigues, Jaqueline da Silva; Vale, Valdicley VieiraThis study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancer...
In silico study of diperpens isolated from Portulaca pilosa L and their correla...
Brandão, Dayse Lúcia do Nascimento; Martins, Hanna Patricia dos Santos; Tomaz, Jéssica Melissa Oliveira; Ferreira, Gleison GonçalvesThis study reports the results obtained in the in silico study for the prediction of biological activity of diterpenes present in P. pilosa, relating these results to use claims, pharmacokinetic and toxicological aspects. Several programs were used to predict biological activities, toxicity, pharmacokinetics and physical chemical properties. Prediction studies suggest that healing activity was related to friede...
Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a pl...
Vale, Valdicley Vieira; Vilhena, Thyago da Costa; Trindade, Rafaela Cabral dos Santos; Ferreira, Márlia Regina C.; Percário, SandroBackground: Plasmodium falciparum has become resistant to some of the available drugs. Several plant species are used for the treatment of malaria, such as Himatanthus articulatus in parts of Brazil. The present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of H. articulatus. Methods: Ethanol and dichloromethane extracts were obtained from the powder ...