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Design of cationic lipid nanoparticles for ocular delivery: Development, charac...
Fangueiro, JF; Andreani, T; Egea, MA; Garcia, ML; Souto, SB; Silva, AM; Souto, EBIn the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN dispersion obtai...
Date: 2014
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Origin: Repositório Científico do Hospital de Braga