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Analysis of BCL11A gene polymorphisms and hemolysis parameters in patients with...

Laurentino,Marilia R.; Barbosa,Maritza C.; Santos,Talyta Ellen J.; Perdigão,Anne Caroline B.; Araújo,Fernanda M. C.; Lemes,Romelia P. G.

ABSTRACT Introduction: Patients with sickle-cell disease (SCD) present chronic hemolysis with increased serum biomarkers. Genetic polymorphisms of the BLC11A gene modulate fetal hemoglobin (HbF), thus reducing hemolysis Objective: To associate the polymorphisms of BCL11A gene with the hemolysis markers: reticulocyte, bilirubin, uric acid, lactate dehydrogenase (LDH), and methemoglobin (MetHb) in SCD patients. M...

Date: 2018   |   Origin: Oasisbr
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