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Chronic thromboembolic pulmonary hypertension: a comprehensive review of pathog...

Cazeiro, Daniel; Azaredo Raposo, Miguel; Guimarães, Tatiana; Lousada, Nuno; Jenkins, David; Inácio, João R.; Moreira, Susana; Mineiro, Ana

Chronic thromboembolic pulmonary hypertension (CTEPH) is part of group 4 of the pulmonary hypertension (PH) classification and generally affects more than a third of patients referred to PH centers. It is a three-compartment disease involving proximal (lobar-to-segmental) and distal (subsegmental) pulmonary arteries that are obstructed by persistent fibrothrombotic material, and precapillary pulmonary arteries ...


Right atrium crossover

Brito, Joana; Plácido, Rui; Matos, Pedro

A 48-year-old woman with no relevant past medical history was referred for coronary computed tomography angiography (CCTA) due to complaints of atypical angina lasting for 2 months. The CCTA depicted a coronary calcium score of 0 and no atherosclerotic disease. However, during the assessment of the coronary anatomy, an abnormal right coronary artery (RCA) course was observed (Panels A, B, and C), showing a prox...


Arterial hypertension, heart failure, angina pectoris, myocardial infarction, a...

Brito, Joana; Caldeira, Daniel; Gregório, Catarina; Plácido, Rui; Pinto, Fausto J.

COVID-19 infection is associated with significant complications affecting multiple organs other than the respiratory system. In fact, there seems to be a bidirectional relation between cardiovascular disease and viral infection, as patients with prior cardiac comorbidities are at a higher risk of adverse events during infection, and COVID-19 infection seems to exponentiate the risk of acute and long-term cardia...


Multidimensional CT approach to predict hemodynamics in pulmonary hypertension

Brito, Joana; Alves da Silva, Pedro; Cazeiro, Daniel; Azaredo Raposo, Miguel; Lousada, Nuno; Inácio, João R.; Guimarães, Tatiana; Almeida, Ana G.

Aim: Computed tomographic pulmonary angiography (CTPA) allows an excellent visualization of heart chambers and vessels, which may be associated with hemodynamic status in pulmonary hypertension, obviating the need for repetitive right heart catheterization (RHC). In this study, we aimed to evaluate the capacity of CTPA to predict severe hemodynamics and to correlate with clinical status and events. Material and...


Pulmonary arterial hypertension with features of venous involvement: a detectiv...

Cazeiro, Daniel; Plácido, Rui; Azaredo Raposo, Miguel; Brito, Joana; Borba, Alexandra; Guimarães, Tatiana; Pinto, Eugénia; Freitas, Pedro

Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis are rare types of histopathological substrates within the spectrum of pulmonary arterial hypertension (PAH) with a very poor prognosis. They are characterized by a widespread fibroproliferative process of the small caliber veins and/or capillaries with sparing of the larger veins, resulting in a pre-capillary pulmonary hypertension ...


Coronary artery calcium identified on non-gated chest CT scans: a wasted opport...

Valente Silva, Beatriz; Menezes, Miguel Nobre; Plácido, Rui; Jorge, Claudia; Rigueira, Joana; Garcia, Ana Beatriz; Martins, Ana Margarida

Background: Coronary artery calcium (CAC) evaluated on dedicated cardiac computed tomography (CT) is an independent predictor of cardiovascular events. This study aimed to evaluate the correlation between CAC detected on non-gated standard chest CT and coronary lesions on coronary angiography (CAG) and determine its impact on prognosis. Methods: Consecutive patients who underwent CAG due to acute coronary syndr...


Prognostic Accuracy of the Modified CHA2DS2-VASc Score in COVID-19 Patients Adm...

Valente Silva, Beatriz; Plácido, Rui; Jorge, Cláudia; Mendonça, Carlos; Urbano, Maria Luísa; Rodrigues, Tiago; Brito, Joana; Alves da Silva, Pedro

Introduction: Risk factors comprising the CHA2DS2VASc score are recognized as risk factors for venous thromboembolism and mortality in COVID-19 patients. A modified CHA2DS2VASc score (M-CHA2D2VASc), developed by changing gender criteria from female to male, has been proposed to predict in-hospital mortality in COVID-19 patients. The aim of this study was to evaluate the prognostic accuracy of M-CHA2D2VASc for a...

Date: 2022   |   Origin: Acta Médica Portuguesa

Comparison of 5 acute pulmonary embolism mortality risk scores in patients with...

Rodrigues, Tiago; Valente Silva, Beatriz; Plácido, Rui; Mendonça, Carlos; Urbano, Maria Luísa; Rigueira, Joana; Almeida, Ana G.; Pinto, Fausto J.

Objective: Pulmonary embolism (PE) is a common complication of SARS-CoV-2 infection. We aimed to explore the short-term outcomes among patients with acute PE and COVID-19 and to further determine and compare the performance of the different prognostic scores (PESI, sPESI, BOVA, FAST and ESC scores) for risk-stratification in this scenario. Methods: Retrospective single-centre study of 85 patients with SARS-CoV-...


The national students survey applied to Portuguese Biomedical Laboratory Scienc...

Mendes, Fernando; Nogueira, António José M.; Barbeira, Marisa; Plácido, Rui; Fernandes, Sílvia; Abreu, Renato

Assessment of students’ experience and perceptions of the academic quality of particular programmes, course units and teachers are currently widespread and encouraged. Internationally, student feedback is highly valued by educational institutions, and it is used to improve teaching effectiveness and overall educational quality, as well as to inform prospective students and other stakeholders. The few measures o...

Date: 2021   |   Origin: Biblioteca Digital do IPB

Pulmonary embolism and COVID-19: a comparative analysis of different diagnostic...

Valente Silva, Beatriz; Jorge, Cláudia; Plácido, Rui; Mendonça, Carlos; Urbano, Maria Luísa; Rodrigues, Tiago; Brito, Joana; Alves da Silva, Pedro

Objective: Pulmonary embolism (PE) is a common complication of SARS-CoV-2 infection. Several diagnostic prediction rules based on pretest probability and D-dimer have been validated in non-COVID patients, but it remains unclear if they can be safely applied in COVID-19 patients. We aimed to compare the diagnostic accuracy of the standard approach based on Wells and Geneva scores combined with a standard D-dimer...


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