13 documents found, page 1 of 2
Abdominal Hypoperfusion and Acute Kidney Injury in the Critically Ill Patient w...
Pereira, Rui; Lopes, Diogo; Brandão Machado, Sara; Val-Flores, Luís; Caeiro, Fernando; Perdigoto, Rui; Marcelino, Paulo; Saliba, FaouziReduced abdominal perfusion pressure (APP) is an underdiagnosed potential pathophysiological mechanism for acute kidney injury (AKI) in the patient with liver cirrhosis and ascites. This study aimed to analyze the prevalence of abdominal hypoperfusion (AhP) (APP <60 mm Hg) and the impact of APP on AKI in critically ill patients with liver cirrhosis. This was a post hoc analysis from a prospective cohort study s...
Referral to Liver Transplant
Sousa Cardoso, Filipe; Sousa, Mónica; Bagulho, Luís; Mendes, Milena; Mateus, Elia; Glória, Helena; Lamelas, Jorge; Bicho, Luís; Mega, RaquelPublisher Copyright: © 2025 The Author(s).; Introduction: The referral of patients with cirrhosis to liver transplant (LT) is a multi-stage, complex process. There is a lack of data on potential challenges to this process. We aimed to characterize challenges faced by Portuguese referring clinicians. Methods: This was a cross-sectional survey from Curry Cabral Hospital, Lisbon, Portugal. The survey was open for ...
Central Pontine and Extrapontine Myelinolysis: Experience from a Single Liver T...
Alexandre Fernandes, Melissa; Miranda, Sandra; Marcelino, Paulo; Mega, Inês; Machado, João; Perdigoto, Rui; Barroso, EduardoIntroduction: Central pontine and extrapontine myelinolysis(CPEPM) is a rare demyelinating syndrome. It has been observedto be more prevalent in liver transplant recipients, withworse prognosis. Rapid corrections of hyponatremia and immunosuppressiveagents, such as calcineurin inhibitors, havebeen pointed as possible causes for the development of thispathology.Methods: The authors report a review of five patien...
Tuberculosis in Liver Transplant Recipients: A Report of Eight Cases During a F...
Póvoas, Diana; Machado, João; Perdigoto, Rui; Morbey, Ana; Veloso, Júlio; Glória, Helena; Mateus, Élia; Martins, Américo; Maltez, FernandoIntroduction: Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. Tuberculosis incidence in liver transplant recipients is not precisely known, but it is estimated to be higher than among the general population. Tuberculosis in liver transplant recipients is particularly challenging because of the atypical clinical presentation and side effects of the ant...
Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular ...
Nunes, Raquel J.; Oliveira, Paula de; Lages, Ana; Becker, Jörg D.; Marcelino, Paulo; Barroso, Eduardo; Perdigoto, Rui; Kelly, Jeffery W."Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has cri...
Transthyretin proteins regulate angiogenesis by conferring different molecular ...
Nunes, Raquel J.; de Oliveira, Paula; Lages, Ana; Becker, Jörg D.; Marcelino, Paulo; Barroso, Eduardo; Perdigoto, Rui; Kelly, Jeffery W.Familial amyloidotic polyneuropathy (FAP) has a high prevalence in Portugal, and the most common form of hereditary amyloidosis is caused by an amyloidogenic variant of transthyretin (TTR) with a substitution of methionine for valine at position 30 (V30M). Until now, the available efficient therapy is liver transplantation, when performed in an early phase of the onset of the disease symptoms. However, transpla...
Hepatite Autoimune - casuística de um serviço de Medicina Interna
Vaio, Teresa; Ferreira, Paulo; Santos, Arsénio; Simão, Adélia; Perdigoto, Rui; Santos, Rui; Carvalho, Armando; Porto, ArmandoIntrodução: A hepatite auto-imune (HAI) é uma inflamação hepática de causa desconhecida, caracterizada pela presença de hepatite de interface na biopsia hepática, de hipergamaglobulinemia e de auto-anticorpos característicos. Objectivo: Avaliar as características clínicas, laboratoriais e histológicas, a resposta à terapêutica e o prognóstico da hepatite auto-imune. Métodos: Análise dos processos clínicos dos d...
Autoimmune hepatitis in an Internal Medicine ward
Vaio, Teresa; Ferreira, Paulo; Santos, Arsénio; Simão, Adélia; Perdigoto, Rui; Santos, Rui; Carvalho, Armando; Porto, ArmandoIntroduction: Autoimmune Hepatitis (AIH) is a hepatocellular inflammation of unknown cause, characterised by the presence of interface hepatitis on liver biopsy, and hypergammaglobulinaemia and autoantibodies in serum.Objective: To characterise clinical, laboratory and histological features, as well as the outcome, of AIH.Methods - Retrospective analysis of AIH cases admitted between 1987 and 2002 in an Interna...
Sources of glucose production in cirrhosis by 2H2O ingestion and 2H NMR analysi...
Perdigoto, Rui; Furtado, Alexandre L.; Porto, Armando; Rodrigues, Tiago B.; Geraldes, Carlos F. G. C.; Jones, John G.Plasma glucose 2H enrichment was quantified by 2H NMR in patients with cirrhosis (n=6) and healthy subjects (n=5) fasted for 16 h and given 2H2O to ~0.5% body water. The percent contribution of glycogenolysis and gluconeogenesis to glucose production (GP) was estimated from the relative enrichments of hydrogen 5 and hydrogen 2 of plasma glucose. Fasting plasma glucose levels were normal in both groups (87±7 an...
Integration of [U-13C]glucose and 2H2O for quantification of hepatic glucose pr...
Perdigoto, Rui; Rodrigues, Tiago B.; Furtado, Alexandre L.; Porto, Armando; Geraldes, Carlos F. G. C.; Jones, John G.Glucose metabolism in five healthy subjects fasted for 16 h was measured with a combination of [U-13C]glucose and 2H2O tracers. Phenylbutyric acid was also provided to sample hepatic glutamine for the presence of 13C-isotopomers derived from the incorporation of [U-13C]glucose products into the hepatic Krebs cycle. Glucose production (GP) was quantified by 13C NMR analysis of the monoacetone derivative of plasm...