4 documents found, page 1 of 1
Stress conditions in the host induce persister cells and influence biofilm form...
Fraiha, Rafael Ovando; Pereira, Ana Paula Ramos; Brito, Eliana da Costa Alvarenga; Borges, Clayton Luiz; Parente, Ana Flávia AlvesINTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in...
Overview of artemisinin effectiveness during outset years of its implementation...
Pinto, Raquel de Medeiros; Sampaio, Vanderson de Souza; Melo, Gisely Cardoso de; Alecrim, Maria das Graças Costa; Mattos, KarineBACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malari...
Overview of artemisinin effectiveness during outset years of its implementation...
Pinto, Raquel de Medeiros; Sampaio, Vanderson de Souza; Melo, Gisely Cardoso de; Costa Alecrimm, Maria das Gracas; Mattoss, KarineMade available in DSpace on 2019-10-06T00:01:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2019-10-09T18:34:40Z : No. of bitstreams: 1 S0074-02762019000100320.pdf: 970993 bytes, checksum: 3b020cb8d2ae9b27e9127d6bc5080a06 (MD5); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); BACKGROUND The elimination of malaria depends on the blocking of transmiss...
Avaliação da atividade antiproliferativa e da inibição das topoisomerases por e...
Perdomo, Renata TrentinAs DNA Topoisomerases são classes de enzimas que controlam a topologia do DNA e são expressas de 25 a 300 vezes mais em tecidos tumorais sendo alvos importantes no desenvolvimento de drogas anti-câncer. Importantes quimioterápicos anti-câncer inibidores das topoisomerases I e II são originados de plantas. Assim, o objetivo deste trabalho foi avaliar a atividade antiproliferativa de extratos e substâncias puras ...