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Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...

Pereira, AS; Gouveia, Alexandra; Tomada, N; Rodrigues, AR; D Neves

Cardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1 alpha-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fr...


Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...

Pereira, AS; Gouveia, AM; Tomada, N; Rodrigues, AR; Neves, D

Cardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fragment...


Occurrence and molecular characterisation of class 1 integrons in Acinetobacter...

Pereira, AS; Domingues, S; Mendo, S; Duarte, A; Silva, GJ da


Arrest in ciliated cell expansion on the bronchial lining of adult rats caused ...

Oliveira, MJR; Pereira, AS; ferreira, pg; Guimaraes, L; Freitas, D; A Carvalho; Grande, NR; AP Águas

Workers chronically exposed to high-intensity/low-frequency noise at textile plants show increased frequency of respiratory infections. This phenomenon prompted the herein investigation on the cytology of the bronchial epithelium of Wistar rats submitted to textile noise. Workplace noise from a cotton-mill room of a textile factory was recorded and reproduced in a sound-insulated animal room. The Wistar rats we...


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