5 documents found, page 1 of 1
Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction ...
Mendes, Rita; Graça, Gonçalo; Silva, Fernanda; Guerreiro, Ana C L; Gomes-Alves, Patrícia; Serpa, Jacinta; Boghaert, Erwin R; Alves, Paula M; Félix, AnaPredicting patient response to treatment and the onset of chemoresistance are still major challenges in oncology. Chemoresistance is deeply influenced by the complex cellular interactions occurring within the tumor microenvironment (TME), including metabolic crosstalk. We have previously shown that ex vivo tumor tissue cultures derived from ovarian carcinoma (OvC) resections retain the TME components for at lea...
Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor m...
Cox, Megan C.; Mendes, Rita; Silva, Fernanda; Mendes, Teresa F.; Zelaya-Lazo, Adelyn; Halwachs, Kathleen; Purkal, Julie J.; Isidro, Inês A.; Félix, AnaFunding Information: This work was supported by AbbVie and by iNOVA4Health – UIDB/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Educação e Ciência, through national funds. RM and TFM were recipients of PhD fellowships funded by FCT (SFRH/BD/132163/2017 and PD/BD/128377/2017, respectively) and CB was funded by “The Discoveries Centre for Regenerative an...
Targeting Tumor Microenvironment for Cancer Therapy
Roma-Rodrigues, Catarina; Mendes, Rita; Baptista, Pedro V.; Fernandes, Alexandra R.This work was funded by the Applied Molecular Biosciences Unit-UCIBIO, which is financed by national funds from FCT/MCTES (UID/Multi/04378/2019) and by Fundacao para a Ciencia e Tecnologia, Post-Doc grant SFRH/BPD/124612/2016 to C.R.-R.; Cancer development is highly associated to the physiological state of the tumor microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from diffe...
Combination of chemotherapy and Au-nanoparticle photothermy in the visible ligh...
Pedrosa, Pedro; Mendes, Rita; Cabral, Rita; Martins, Luísa M. D. R. S.; Baptista, Pedro V.; Fernandes, Alexandra R.This work was supported by the Unidade de Ciencias Biomoleculares Aplicadas - UCIBIO which is financed by national funds from FCT/MEC (UID/Multi/04378/2013; UID/QUI/00100/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728); PP for PD/BD/105734/2014; RM for SFRH/BD/132163/2017. I. Coutinho for access to laser and P. Martins for initial induction of HCT116 DOXR.; D...
Photothermal enhancement of chemotherapy in breast cancer by visible irradiatio...
Mendes, Rita; Pedrosa, Pedro; Lima, João C.; Fernandes, Alexandra R.; Baptista, Pedro V.Unidade de Ciencias Biomoleculares Aplicadas - UCIBIO - FCT/MEC (UID/Multi/04378/2013) ERDF (POCI-01-0145-FEDER-007728; PD/BD/105734/2014); Photothermal Therapy (PTT) impact in cancer therapy has been increasing due to the enhanced photothermal capabilities of a new generation of nanoscale photothermal agents. Among these nanoscale agents, gold nanoshells and nanorods have demonstrated optimal properties for tr...