2 documents found, page 1 of 1
Genomic profiling of gastrointestinal stromal tumours using whole-exome sequencing
Pereira, Ana Rafaela SilvaGastrointestinal stromal tumours (GISTs) are rare tumours, yet they constitute the most prevalent mesenchymal neoplasm of the gastrointestinal tract, affecting mostly the stomach and small intestine. Although the majority of GISTs have alterations in the KIT and PDGFRA proto-oncogenes, 15% are considered wild-type GIST. KIT and PDGFRA-mutated GISTs are more sensitive to tyrosine kinase inhibitors (TKIs) than wi...
Síndrome do Roubo da Subclávia e Síndrome do Roubo coronário-subclávio : um res...
Barbosa, Maria Lucianny Lima; Pereira, Ana Rafaela Silva; Moura, Rosielle Alves de; Costa Sobrinho, Osvaldo Pereira da; Pessoa, Daniela França Barroshe syndrome of coronary-subclavian steal is defined as the reversed blood fl ow in a coronary artery by means of a grafting of the left internal mammary artery tow ard the middle-distal subclavian, and occurs due to severe stenosis or total occlusion of th e proximal portion of the latter. It is a disease with significant morbidity with po ssible complications such as thrombosis, anoxia and death. The objective...