80 documents found, page 1 of 8
The potential of DNA methylation as a biomarker for age-related macular degener...
Ghannai, Salema; Ribeiro, Edna; Pereira, Bruno; Brito, Miguel; Camacho, PedroAge-related macular degeneration (AMD) is a multifactorial disease influenced by genetic and environmental factors, yet its pathogenesis remains incompletely understood. DNA methylation, increasingly recognized as a disease indicator, has been linked to AMD and may represent a promising biomarker or therapeutic target. This systematic review, conducted according to PRISMA 2020 guidelines, analyzed 13 studies ad...
Epigenetic Signatures of DNMTs and Retinal Structural Changes in Age-Related Ma...
Afonso, Ana; Nobre, Diana; Lino, Leonor; Ribeiro, Edna; Pereira, Bruno; Ginete, Catarina; Silva, Carina; Brito, Miguel; Camacho, Pedro; Pereira, BrunoIntroduction: Age-related macular degeneration (AMD) is one of the leading causes of irreversible visual loss in the elderly. Identifying effective biomarkers is essential due to the limited therapeutic options in the early stages. Epigenetic alterations, such as DNA methyltransferase (DNMT) expression, have been implicated in AMD pathogenesis; however, their association with structural changes in the choroid a...
Foveal avascular zone area measurement in diabetic patients: superficial, deep ...
Pereira, Bruno; Faria, Ross; Domingues, Cátia; Barros, Ana; Varandas, Teresa; Henriques, José; Nascimento, João; Carolino, Elisabete; Camacho, PedroPurpose: To compare differences in the foveal avascular zone (FAZ) area, measured in the Superficial Vascular Complex (SVC), Deep Vascular Complex (DVC), and a combined analysis of both (SDVC), using two Spectral Domain OCT angiography (OCT-A) protocols, High Speed (HS) and High Resolution (HR). Methods: A total of 26 eyes of diabetic patients, with and without macular oedema, were examined with two different f...
DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Rosa, Paulo Caldeira; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoBackground/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
Neurodegeneration and choroidal vascular features on OCT in the progression to ...
Costa, Inês; Carvalho, Ana; Andrade, Helton; Pereira, Bruno; Camacho, PedroAim: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. Methods: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 partici...
Ezrin protein’s role on cell migration in gastric cancer and identification of ...
Silva , Sara; Mesquita, Patrícia; Pereira, Bruno; Almeida, RaquelBackground: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths, often diagnosed in late stages of the disease, limiting treatment options [1-2]. The absence of new therapies and proper diagnosis calls for an exploration of different potential targets. Epitranscriptomics studies RNA chemical modifications such as N6-methyladenosine (m6A), lately studied to understand its effect on cancer pr...
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Caldeira Rosa, Paulo; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoAge-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (, , and ) in AMD patients and explore divergent expression patterns across different stages of AMD. : Thirty-eight AMD patients were prospectively enrolled and stratified by disease seve...
Crononutrição e padrão de sono em profissionais de saúde com trabalho por turnos
Pinto, Ana Beatriz; Santos, Zélia; Pitta-Grós, Mónica; Barrigas, Carlos; Mendes, Lino; Ginete, Catarina; Belo, Joana; Silva, Ana Lúcia; Camacho, PedroIntrodução – Ao longo dos anos, os organismos evoluíram biologicamente, desenvolvendo ritmos circadianos. Os profissionais de saúde operam frequentemente em turnos noturnos, estando expostos à luz artificial, trabalhando e alimentando-se no período circadiano noturno, o que aumenta o risco de desalinhamento circadiano. Objetivos – Esta revisão narrativa tem como objetivos aferir o impacto do trabalho por turnos...
Crononutrição e padrão de sono em profissionais de saúde com trabalho por turnos
Pinto, Ana Beatriz; Santos, Zélia; Pitta-Grós, Mónica; Barrigas, Carlos; Mendes, Lino; Ginete, Catarina; Belo, Joana; Silva, Ana Lúcia; Camacho, PedroIntrodução – Ao longo dos anos, os organismos evoluíram biologicamente, desenvolvendo ritmos circadianos. Os profissionais de saúde operam frequentemente em turnos noturnos, estando expostos à luz artificial, trabalhando e alimentando-se no período circadiano noturno, o que aumenta o risco de desalinhamento circadiano. Objetivos – Esta revisão narrativa tem como objetivos aferir o impacto do trabalho por turnos...
Thickness Profile of the Ganglion Cell Complex and Choroid in Patients with Per...
Condelipes, Ana; Correia, Daniela; Fernandes, Inês; Silva, Tiago; Correia, Eduardo; Pereira, Bruno; Camacho, PedroPurpose: About 40 % of patients with diabetic macular edema (DME) do not respond optimally to first-line treatment with intravitreal injection of anti-vascular endothelial growth factor (AVEGF). Evidence suggests that additional vascular and neurodegenerative mechanisms may be involved. This study aimed to characterise the thickness of the Ganglion Cell Complex (GCC) and investigate the Choroidal Vascularity In...