4 documents found, page 1 of 1
The long-term culture of human fibroblasts reveals a spectroscopic signature of...
Magalhães, Sandra; Almeida, Idália; Pereira, Cátia D.; Rebelo, Sandra; Goodfellow, Brian J.; Nunes, AlexandraAging is a complex process which leads to progressive loss of fitness/capability/ability, increasing susceptibility to disease and, ultimately, death. Regardless of the organism, there are some features common to aging, namely, the loss of proteostasis and cell senescence. Mammalian cell lines have been used as models to study the aging process, in particular, cell senescence. Thus, the aim of this study was to...
Widespread protein aggregation across the mouse lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Helguero, Luísa; Soares, Ana RaquelAging is characterized by a gradual decline in overall organismal fitness across the lifespan, and greatly enhances the risk for chronic diseases, as neuropathological disorders, diabetes, cancer and cardiovascular diseases. One of the hallmarks of aging is the loss of proteostasis, a regulated process responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis net...
Evaluation of proteostasis across mammalian lifespan
Martins, Filipa; Francisco, Stephany; Sousa, Jéssica; Pereira, Cátia D.; Correia, Liliana; Camões, Fátima; Soares, Ana Raquel; Rebelo, SandraProteostasis is a highly regulated process involving the proteostasis network responsible for maintaining the cellular proteome. When proteostasis is altered, proteome and proteostasis network disruptions occur, leading to accumulation of protein aggregates, characteristic of several age-related diseases. Previous work performed in Caenorhabditis elegans and zebrafish unveiled asymptomatic protein aggregation (...
Descriptive Analysis of LAP1 Distribution and That of Associated Proteins throu...
Serrano, Joana B.; Martins, Filipa; Sousa, João Carlos; Pereira, Cátia D.; Pelt, Ans M. M. van; Rebelo, Sandra; Silva, Odete A. B. da Cruz eSpermatogenesis comprises highly complex differentiation processes. Nuclear envelope (NE) proteins have been associated with these processes, including lamins, lamina-associated polypeptide (LAP) 2 and the lamin B-receptor. LAP1 is an important NE protein whose function has not been fully elucidated, but several binding partners allow predicting putative LAP1 functions. To date, LAP1 had not been associated wit...