6 documents found, page 1 of 1
Exploring lactoferrin-loaded exosomes as a novel therapeutic strategy for color...
Novo, Inês C.; Pereira, Cátia S.; Rodrigues, L. R.; Ferreira, DéboraColorectal cancer (CRC) is characterized by the uncontrolled proliferation of abnormal cells in the lining of colon or rectum. Primary treatment modalities against CRC include surgical intervention and chemotherapy, which often fail. Hence, there is a pressing need for innovative targeted therapies. Bovine lactoferrin (bLf), a natural milk-derived protein, has shown selective cytotoxicity against CRC cells. How...
Leukocyte Imbalances in Mucopolysaccharidoses Patients
Lopes, Nuno; Maia, Maria L.; Pereira, Cátia S.; Mondragão-Rodrigues, Inês; Martins, Esmeralda; Ribeiro, Rosa; Gaspar, Ana; Aguiar, PatrícioMucopolysaccharidoses (MPSs) are rare inherited lysosomal storage diseases (LSDs) caused by deficient activity in one of the enzymes responsible for glycosaminoglycans lysosomal degradation. MPS II is caused by pathogenic mutations in the IDS gene, leading to deficient activity of the enzyme iduronate-2-sulfatase, which causes dermatan and heparan sulfate storage in the lysosomes. In MPS VI, there is dermatan s...
How can a milk protein selectively kill cancer cells? Mechanisms underlying lac...
Pereira, Cátia S.; Guedes, Joana P.; Chaves, Susana R.; Gerós, Hernâni; Rodrigues, L. R.; Côrte-Real, ManuelaLactoferrin (Lf) is an iron-binding protein abundant in milk that has been shown to exhibit anticancer activity. Since Lf is non-toxic to cancer cells (1) and is well tolerated in humans (2), this protein has a huge potential to be used in cancer therapy. However, the targets and mechanisms underlying its selective anticancer activity are poorly elucidated, which limits its clinical exploitation. The recruitmen...
Effect of microstructural changes in the biological behavior of magnetron sputt...
Costa, Diogo Emanuel Carvalho; Borges, Joel Nuno Pinto; Mota, Maria F.; Rodrigues, Marco S.; Pereira-Silva, Patrícia; Ferreira, Armando José BarrosThis work is focused on the evaluation of the correlation between the microstructural changes of zinc oxide (ZnO) thin films and its biological behavior. For this study, ZnO thin films were prepared by reactive magnetron sputtering, using different deposition times and reactive gas (O2) flows, and tested against a fungal pathogenic species, Candida albicans. Results showed that the increase of thickness of the ...
Resveratrol-loaded lipid nanocarriers are internalized by endocytosis in yeast
Barbosa, Célia; Pereira, Cátia S.; Soares, Inês; Martins, Viviana; Terra-Matos, Joana; Côrte-Real, Manuela; Lúcio, M.; Real Oliveira, M. Elisabete C.D.Different positive pharmacological effects have been attributed to the natural product resveratrol (RSV), including antioxidant, antiaging, and cancer chemopreventive properties. However, its low bioavailability and rapid metabolic degradation has led to the suspicion that many of the biological activities of this compound observed in vitro may not be attainable in humans. To improve its bioavailability and pha...
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...
Pereira, Cátia S.; Guedes, J.; Gonçalves, Marília; Loureiro, Luís; Castro, Lisandra; Gerós, Hernâni; Rodrigues, L. R.; Côrte-Real, ManuelaBreast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, significant challenges remain in the treatment of metastatic breast cancer. The recruitment of the vacuolar H+-ATPase (V-H+-ATPase) to the plasma membrane, where it mediates the acidification of the tumor microenvironment (TME), is a recognized feature involved in the acquisition of a metastatic phen...