13 documents found, page 1 of 2
Development and In Vitro Validation of Antibacterial Paints Containing Chloroxy...
Querido, MM; Paulo, I; Hariharakrishnan, S; Rocha, D; Barbosa, N; Gonçalves, D; Dos Santos, RG; Bordado, JM; Teixeira, JP; Pereira, CCThe establishment of self-disinfecting surfaces is an important method to avoid surface contamination. Recently, paints with antimicrobial properties have been developed to be applied on different surfaces, avoiding contamination with pathogens. In this work, self-disinfecting paints containing Chloroxylenol (CLX), Terpineol (TRP), and a mixture of both substances were developed. The goal was to evaluate and va...
In Vitro Cyto-and Genotoxicity Assessment of Antibacterial Paints with Triclosa...
Querido, MM; Rosário, F; Bessa, MJ; Mendes, F; Teixeira, JC; Teixeira, JP; Pereira, CCSurfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its bioc...
Biological risk assessment: A challenge for occupational safety and health prac...
Carvalhais, C; Querido, M; Pereira, CC; Santos, JBackground: The COVID-19 global pandemic brought several challenges to occupational safety and health practice. One of these is the need to (re)assess the occupational risks, particularly, biological risks. Objective: The purpose of this work is to promote guidance to occupational safety and health practitioners when conducting a biological risk assessment in this context. Methods: The main steps of the biologi...
Auto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol-A...
Machado Querido, M; Paulo, I; Hariharakrishnan, S; Rocha, D; Pereira, CC; Barbosa, N; Bordado, JM; Teixeira, JP; Galhano dos Santos, REnvironmental surface contamination with microorganisms is a serious concern worldwide. Triclosan and isoborneol present good antimicrobial activity. Their immobilisation to paint substrates allows for development of a material that stays effective over a longer time. In this work, we disclosed the preliminary studies to evaluate the antimicrobial activity of the active molecule after being functionalised with ...
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony a...
Querido, MM; Paulo, I; Hariharakrishnan, S; Rocha, D; Barbosa, N; Galhano dos Santos, R; Bordado, JM; Teixeira, JP; Pereira, CCThe risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in en...
Development of a new multiplex PCR to detect prevalent species of house dust mi...
Oliveira, AS; Gaspar, C; Rolo, J; Pereira, CC; Palmeira-de-Oliveira, R; Teixeira, JP; Martinez-de-Oliveira, J; Palmeira-de-Oliveira, ADermatophagoides pteronyssinus and Dermatophagoides farinae are the most common House Dust Mite (HDM) species in home environments worldwide and responsible for HDM allergy. Since the prevalence of HDM-related clinical conditions is linked to exposure to the mite itself, the detection of HDM in the human households gains importance. We aimed to develop a fast and accessible multiplex PCR to detect and distingui...
Kinetics of radium-223 and its effects on survival, proliferation and DNA damag...
Marques, IA; Abrantes, AM; Pires, AS; Neves, AR; Caramelo, FJ; Rodrigues, T; Matafome, P; Tavares-da-Silva, E; Gonçalves, AC; Pereira, CC; Teixeira, JPBackground Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to ch...
Self-disinfecting surfaces and infection control
Querido, MM; Aguiar, L; Neves, P; Pereira, CC; Teixeira, JPAccording to World Health Organization, every year in the European Union, 4 million patients acquire a healthcare associated infection. Even though some microorganisms represent no threat to healthy people, hospitals harbor different levels of immunocompetent individuals, namely patients receiving immunosuppressors, with previous infections, or those with extremes of age (young children and elderly), requiring ...
Optimization of the harvesting and freezing conditions of human cell lines for ...
Bessa, MJ; Brandão, F; Querido, MM; Costa, C; Pereira, CC; Valdiglesias, V; Laffon, B; Carriere, M; Teixeira, JP; Fraga, SThe comet assay is a commonly used method for in vitro and in vivo genotoxicity assessment. This versatile assay can be performed in a wide range of tissues and cell types. Although most of the studies use samples immediately processed after collection, frozen biological samples can also be used. The present study aimed to optimize a collection and freezing protocol to minimize the DNA damage associated with th...
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel D...
Pereira, CC; Durães, C; Coelho, R; Grácio, D; Silva, M; Peixoto, A; Lago, P; Pereira, M; Catarino, T; Pinho, S; Teixeira, JP; Macedo, G; Annese, VInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Croh...