4 documents found, page 1 of 1
Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients
Marques, AP; Resende, R; Silva, DF; Batista, M; Pereira, D; Wildenberg, B; Morais, S; Macedo, A; Pais, C; Melo, JB; Madeira, N; Pereira, CFThis study aims to evaluate whether mitochondrial changes occur in the early stages of bipolar disorder (BD). Using fibroblasts derived from BD patients and matched controls, the levels of proteins involved in mitochondrial biogenesis and dynamics (fission and fusion) were evaluated by Western Blot analysis. Mitochondrial membrane potential (MMP) was studied using the fluorescent probe TMRE. Mitochondrial morph...
A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to m...
Pádua, D; Barros, R; Amaral, AL; Mesquita, P; Freire, AF; Sousa, M; Maia, AF; Caiado, I; Fernandes, H; Pombinho, AR; Pereira, CF; Almeida, RGastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 acti...
Inflamação na Doença Bipolar: Identificação de Novos Alvos Terapêuticos
Oliveira, J; Madeira, N; Costa, MT; Pereira, CFIntrodução: A doença bipolar é um distúrbio mental com origem no conceito “mania”. Trata-se de uma patologia crónica, de natureza cíclica, caracterizada pelo aparecimento de episódios alternados de mania/hipomania com episódios de eutimia/depressão. Com este artigo pretendemos identificar novas abordagens terapêuticas para o tratamento da doença bipolar, tendo em consideração o envolvimento da inflamação na sua...
The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar Disorder...
Pereira, AC; Resende, R; Morais, S; Madeira, N; Pereira, CF