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Nanopartículas de tungsténio para a eletrólise da água: uma abordagem sustentáv...

Ganilho, Catarina Isabel; Cordeiro, Marta; Andreani, Tatiana; Pereira, Carlos M.; Pereira, Ruth

A procura intensa por novas fontes de energia mais sustentáveis, como a produção de hidrogénio através do processo de separação dos componentes da molécula água, tem estado associada à implementação de estratégias e políticas promotoras da neutralidade carbónica das sociedades. Neste sentido, têm sido realizados esforços para explorar catalisadores, para o processo de hidrólise da água, baseados em compostos me...


Electrostatic assembly of anti-listeria bacteriophages on a self-assembled mono...

Fernandes, Paula M. V.; Maciel, Cláudia; Teixeira, Paula; Pereira, Carlos M.; Campina, José M.

The integration of bacteriophages, a particular class of viruses that specifically infect bacteria and archaea, in biosensors for the monitoring of pathogens in foods and beverages is highly desirable. To this end, an increasing focus has been set on the exploration of covalent and physical methods for the immobilization of phages on solid surfaces. This work investigates the electrostatic assembly of tailed ph...


Electrochemistry combined-surface plasmon resonance biosensors: A review

Ribeiro, José; Sales, M. G. F.; Pereira, Carlos M.

Over the years, most of the literature reported applications of electrochemical and surface plasmon resonance (SPR) immunoassays for biosensing but, so far, the combination of the two methods in the same sensing spot for analytical purposes is much less explored and discussed. The aim of this Review is to highlight the great potential of electrochemistry combined-SPR (eSPR) as analytical tool for screening chem...


Electrochemical immunosensor for detection of CA 15-3 biomarker in point-of-care

Rebelo, Tânia S.C.R.; Ribeiro, José A.; Sales, M. Goreti F.; Pereira, Carlos M.

This work reports the development of a simple and rapid electrochemical immunosensor for the determination of breast cancer biomarker Cancer Antigen 15–3 (CA 15–3). Disposable and cost-effective chips, consisting of gold screen-printed electrodes (AuSPEs), were used to develop the portable electrochemical devices for monitoring the biomarker in point-of-care (PoC), under clinical context. The biosensor preparat...


Electrochemistry-assisted surface plasmon resonance biosensor for detection of ...

Ribeiro, José A.; Sales, Maria Goreti F.; Pereira, Carlos M.

In this work, we describe an innovative methodology based on combined surface plasmon resonance (SPR) and electrochemical responses (eSPR) in the same immunoassay for screening CA 153 cancer biomarker with high sensitivity (and selectivity), in a very simple, label-free, accurate, and fully automated manner. Detection was achieved by performing two simple steps. In the first step, direct SPR was used to monitor...


Electrochemical immunosensor for detection of CA 15-3 biomarker in point-of-care

Rebelo, Tânia; Ribeiro, José; Sales, M. G. F.; Pereira, Carlos M.

This work reports the development of a simple and rapid electrochemical immunosensor for the determination of breast cancer biomarker Cancer Antigen 153 (CA153). Disposable and cost-effective chips, consisting of gold screen-printed electrodes (AuSPEs), were used to develop the portable electrochemical devices for monitoring the biomarker in point-of-care (PoC), under clinical context. The biosensor preparation...


Thiophene- and carbazole-substituted N-Methyl-Fulleropyrrolidine acceptors in P...

Gaspar, Hugo; Figueira, Flávio; Strutyński, Karol; Melle-Franco, Manuel; Ivanou, Dzmitry; Tomé, João P. C.; Pereira, Carlos M.; Pereira, Luiz

The impact of fullerene side chain functionalization with thiophene and carbazole groups on the device properties of bulk-heterojunction polymer:fullerene solar cells is discussed through a systematic investigation of material blends consisting of the conjugated polymer poly[(5,6-difluoro-2,1,3-benzothiadiazol-4,7-diyl)-alt-(3,3‴-di(2-octyldodecyl)-2,2′;5′,2″;5″,2‴-quaterthiophen-5,5‴-diyl)] (PffBT4T-2OD) as do...


Electrochemistry-assisted surface plasmon resonance detection of miRNA-145 at f...

Ribeiro, José A.; Sales, Maria Goreti Ferreira; Pereira, Carlos M.

In this work, we combined electrochemical techniques with SPR (eSPR) for the label-free detection of cancer biomarker miRNA-145. Detection was performed in a simple two-step assay. In the first step, the gold sensor surface, previously functionalized with a self-assembled monolayer (SAM) of thiolated RNA probes is incubated with the sample containing the target RNA biomarker. In this step, hybridization of RNA ...


PffBT4T-2OD based solar cells with Aryl-Substituted N-Methyl-Fulleropyrrolidine...

Gaspar, Hugo; Figueira, Flávio; Strutyński, Karol; Melle-Franco, Manuel; Ivanou, Dzmitry; Tomé, João P. C.; Pereira, Carlos M.; Pereira, Luiz

Novel C<sub>60</sub> and C<sub>70</sub> <i>N</i>-methyl-fulleropyrrolidine derivatives, containing both electron withdrawing and electron donating substituent groups, were synthesized by the well-known Prato reaction. The corresponding highest occupied molecular orbital (HOMO)/lowest unoccupied molecular orbital (LUMO) energy levels were determined by cyclic voltammetry, from the onset oxidation and reduction p...


Development of hydroxybenzoic-based platforms as a solution to deliver dietary ...

Teixeira, José; Oliveira, Catarina; Amorim, Ricardo; Cagide, Fernando; Garrido, Jorge; Ribeiro, José A.; Pereira, Carlos M.; Silva, António F. M.

Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention of different pathologies, including diseases with a mi...


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