25 documents found, page 1 of 3
Influência da intervenção osteopática na atividade do sistema imunitário: revis...
Azevedo, César; Pereira, Clara; Oliveira, Fábio; Castro, Inês; Oliveira, Rui; Campelo, Natália; Sousa, HelenaO sistema imunitário apresenta funções vitais de proteção do organismo através de vários órgãos, células e proteínas. Existem vários fatores que influenciam a imunidade, sendo que o papel da intervenção osteopática, potenciando e estimulando a sua resposta, tem sido mencionado como promissor coadjuvante não-farmacêutico de baixo custo que visa modular a secreção de citocinas. Realizar uma análise crítica da qua...
Influência da intervenção osteopática na atividade do sistema imunitário: revis...
Azevedo, César; Pereira, Clara; Oliveira, Fábio; Castro, Inês; Oliveira, Rui; Campelo, Natália; Sousa, HelenaIntrodução: O sistema imunitário apresenta funções vitais de proteção do organismo através de vários órgãos, células e proteínas. Existem vários fatores que influenciam a imunidade, sendo que o papel da intervenção osteopática, potenciando e estimulando a sua resposta, tem sido mencionado como promissor coadjuvante não-farmacêutico de baixo custo que visa modular a secreção de citocinas. Objetivos: Realizar uma...
Design and photo-Fenton performance of Graphene/CuS/Fe3O4 tertiary nanocomposit...
Matos, Renata; Kuźniarska-Biernacka, Iwona; Rocha, Mariana; Belo, João H.; Araújo, João Pedro; Estrada, Ana C.; Lopes, Joana L.; Shah, TushtiThis study describes nanocomposites of graphene flakes (GF) combined with CuS, Fe3O4 and CuS−Fe3O4 nanoparticles prepared by wet chemical methods. The Fe3O4 and/or CuS nanoparticles were directly anchored onto GF without requiring additional chemical treatment. The composition, structure and morphology of the nanocomposites, as well as of the pristine GF and metal oxide/sulfide nanoparticles were characterised ...
Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia
Oliveira, Mariana L.; Veloso, Alexandra; Garcia, Elaine G.; Iyer, Sowmya; Pereira, Clara; Barreto, Vasco M.; Langenau, David M.; Barata, João T.T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric cancer. Amongst the wide array of driver mutations, 10% of T-ALL patients display gain-of-function mutations in the IL-7 receptor α chain (IL-7Rα, encoded by IL7R), which occur in different molecular subtypes of this disease. However, it is still unclear whether IL-7R mutational activation is sufficient to transform T-cell precursors. Also, ...
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso; Neto, João Luís; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta; Raposo, Beatriz; Oliveira, Mariana L.Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVI...
Freitas, Ana Teresa; Calhau, Conceição; Antunes, Gonçalo; Araújo, Beatriz; Bandeira, Matilde; Barreira, Sofia; Bazenga, Filipa; Braz, SandraVitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...
Chronoamperometric magnetogenosensing for simultaneous detection of two Roundup...
Plácido, Alexandra; Pereira, Clara; Barroso, M. Fátima; de-los-Santos-Álvarez, Noemí; Delerue-Matos, CristinaDevelopment of expeditious analytical methods for the detection of genetically modified organisms (GMOs) is increasingly necessary, not only to verify compliance with labelling, but also to help industry to efficiently control the reception of raw materials. On the basis of this, a disposable electrochemical magnetogenoassay is proposed for simultaneous detection of two Roundup Ready (RR) soybean lines GTS 40-3...
Errors in protein synthesis increase the level of saturated fatty acids and aff...
Araújo, Ana Rita D.; Melo, Tânia; Maciel, Elisabete A.; Pereira, Clara; Morais, Catarina M.; Santinha, Deolinda R.; Tavares, Joana F.; Oliveira, HelenaThe occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorpo...
Electrochemical genoassays on gold-coated magnetic nanoparticles to quantify ge...
Plácido, Alexandra; Pereira, Clara; Guedes, Alexandra; Barroso, M. Fátima; Miranda-Castro, Rebeca; Santos-Álvarez, Noemí de-los-The integration of nanomaterials in the field of (bio)sensors has allowed developing strategies with improved analytical performance. In this work, ultrasmall core-shell Fe3O4@Au magnetic nanoparticles (MNPs) were used as the platform for the immobilization of event-specific Roundup Ready (RR) soybean and taxon-specific DNA sequences. Firstly, monodisperse Fe3O4 MNPs were synthesized by thermal decomposition an...
Errors in protein synthesis increase the level of saturated fatty acids and aff...
Araújo, Ana Rita D.; Melo, Tânia; Maciel, Elisabete A.; Pereira, Clara; Morais, Catarina M.; Santinha, Deolinda R.; Tavares, Joana F.; Oliveira, HelenaThe occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorpo...