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Structure-activity relationships for dipeptide prodrugs of acyclovir

Santos, Cledir R.; Capela, Rita; Pereira, Claudia S. G. P.; Valente, Emilia; Gouveia, Luis; Pannecouque, Christophe; De Clercq, Erik; Moreira, Rui

A series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of Herpes Simplex-1 and -2, vaccinia, vesicular stomatitis, cytomegalovirus and varicella zoster viruses. ACV dipeptide esters were very active against herpetic viruses, independently of the rate at which they liberate the p...

Date: 2009   |   Origin: Repositório da Universidade de Lisboa
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