25 documents found, page 1 of 3

Uso apropriado da ecocardiografia transtorácica

Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa...

Introdução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais. Objetivo: Avaliar a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais na eclosão desta patologia. Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860 hipertensos e 852 controlos)...

A variante genética c825t da subunidade β3 da proteína G associa‐se com a hiper...

Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic va...

Additional value of a combined genetic risk score to standard cardiovascular st...

The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic varia...

Genetic Polymorphisms Associated with the Onset of Arterial Hypertension in a P...

Introduction: Arterial hypertension is a complex, multifactorial disease, controlled by genetic and environmental factors.Objective: Evaluate the genetic susceptibility for developing arterial hypertension and its association with the traditional risk factors in the outbreak of this pathology.Material and Methods: Case-control study with 1712 individuals, mean age of 51.0 ± 7.9 years (860 hypertensive patients ...

A variante genética c825t da subunidade 3 da proteína G associa-se com a hipert...

Introduc¸ão: A hipertensão arterial é um problema de Saúde Pública, afeta 25% da populac¸ão adulta mundial. Fatores genéticos e ambientais contribuem para a sua patogénese. O polimorfismo C825T da subunidade 3 da Proteína G (rs5443) favorece a produc¸ão de uma variante alternativa, truncada, que facilita a sinalizac¸ão intracelular, pode interferir na regulac¸ão da pressão arterial. Essa variante genética tem s...

The genetic variant C825T of the beta 3 subunit of G protein is associated with...

Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic va...

Polimorfismos genéticos associados ao aparecimento de hipertensão arterial numa...

Introdução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais. Objetivo: Avaliar a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais na eclosão desta patologia. Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860 hipertensos e 852 controlos)...

Additional value of a combined genetic risk score to standard cardiovascular st...

The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic varia...

Genetic risk score and cardiovascular mortality in a southern european populati...

Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) have yielded conflicting results. Objective: The objective of this study was to evaluate long- term cardiovascular mortality according to the genetic risk score in a Southern European population with CAD. Methods: A cohort of 1464 CAD patients with angiog...