3 documents found, page 1 of 1
Study of hTERT and Histone 3 Mutations in Medulloblastoma
Pereira, Marta Sofia Carvalho Ribeiro Viana; Almeida, Gisele Caravina; Stavale, João Norberto; Malheiro, Susana; Clara, Carlos; Lobo, PatríciaHotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division. Additionally, there are alternative telomere maintenance mechanisms, associated with histone H3 mutations, responsible for disruptin...
Foreign Language Education in the 21st European Context: Exploring New Directio...
Lobo, PatríciaThis article considers the reformulation of foreign language classes as spaces of cultural politics, dynamic social activism and holistic education, in order to enable schools, teachers and students to set the foundation for a more inclusive society. It starts by recognizing some of the challenges of the 21st century European context, addressing the need to explore new directions in the intercultural and pluril...
Substantia nigra neuromelanin-MR imaging differentiates essential tremor from P...
Reimão, Sofia; Lobo, Patrícia; Neutel, Dulce; Correia Guedes, Leonor; Coelho, Miguel; Rosa, Mário Miguel; Azevedo, Pedro; Ferreira, Joana; Abreu, DaisyBackground: Essential tremor (ET) is a very common movement disorder that has no diagnostic markers. Differentiation with Parkinson's disease (PD) can be clinically challenging in some cases, with a high rate of misdiagnosis. Magnetic resonance imaging (MRI) studies have been able to identify neuromelanin changes in the substantia nigra (SN) of PD patients, but they have thus far not been investigated in ET. In...