SNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective w...
Background Gastric cancer results from a multifactorial process and is one of the most common causes of death worldwide. These tumors can arise in the distal stomach (non-cardia) and in the cardia region, presenting different characteristics and frequency of occurrence worldwide. Aims To search for differences between tumors of dif- ferent locations that could explain the presence of cardia tumors, considering ...
The Helicobacter pylori (H. pylori) infection is present in more than half the world’s population and it has been associated with several gastric disorders, as gastritis, peptic ulceration and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterium factors where H. pylori virulence genes seem to play a relevant role. Until now, cagA and vacA genes were studied and establishe...
PEREIRA, E. S. Expressão gênica de Streptococcus mutans em biofilmes produzidos in vitro submetidos à terapia fotodinâmica antimicrobiana. 2011. 70f. Dissertação (Mestrado em Biotecnologia) - Campus de Sobral, Universidade Federal do Ceará, Sobral, 2011.; The early stages of the formation of caries lesions in humans are directly related to the presence of Streptococcus mutans in biofilm. The treatment of diseas...
Gastric cancer (GC) is the third cause of cancer death worldwide. The etiology of gastric cancer is multifactorial and it i s being well established an association with infection by Helicobacter pylori . The genetic susceptibility to GC is postulated by exposure of a large proportion of the population to risk factors, but only part of this people develops the neoplasia. Furtherm ore, the H. pylori pathogenic ch...