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Enhanced borohydride oxidation kinetics with Au@MOF-808 nanocomposite electroca...

Belhaj, Ines; Becker, J. Alexander; Viana, Alexandre M.; Gusmão, Filipe M. B.; Chaves, Miguel; Pereira, Eulália; Sljukic, Biljana; Balula, Salete S.

ABSTRACT: The highly stable metal-organic framework (MOF) composed of[Zr6O4(mu 3-OH)4(OH)6(H2O)6(BTC)2]& sdot;nH2O units (MOF-808) was modified by incorporating gold (Au) nanoparticles and functional groups to enhance electrocatalytic activity for the borohydride oxidation reaction (BOR). Three composite materials (Au@MOF-808, Au@MOF-808-NH2, and Au@MOF-808-SH) were prepared by the incorporation of Au in struct...

Date: 2026   |   Origin: Repositório do LNEG

Towards rapid and low-cost stroke detection Using SERS and Machine Learning

Freitas, Cristina; Eleutério, João; Soares, Gabriela; Enea, Maria; Nunes, Daniela; Fortunato, Elvira; Martins, Rodrigo; Águas, Hugo; Pereira, Eulália

Stroke affects approximately 12 million individuals annually, necessitating swift diagnosis to avert fatal outcomes. Current hospital imaging protocols often delay treatment, underscoring the need for portable diagnostic solutions. We have investigated silver nanostars (AgNS) incubated with human plasma, deposited on a simple aluminum foil substrate, and utilizing Surface-Enhanced Raman Spectroscopy (SERS) comb...


Functional properties and safety considerations of zinc oxide nanoparticles und...

Mendes, Ana Rita; Granadeiro, Carlos M.; Leite, Andreia; Geiss, Otmar; Bianchi, Ivana; Ponti, Jessica; Mehn, Dora; Pereira, Eulália; Teixeira, Paula

Zinc oxide nanoparticles (ZnO NPs) exhibit diverse morphologies and sizes, influencing their functional properties. However, the relationship between their morphology and behavior under varying conditions remains poorly understood. This study provides novel insights by linking ZnO NPs shape to generation of reactive oxygen species (ROS), and to antimicrobial efficacy under varying temperatures. ROS generation w...


Optimizing antimicrobial efficacy: investigating the impact of zinc oxide nanop...

Mendes, Ana Rita; Granadeiro, Carlos M.; Leite, Andreia; Pereira, Eulália; Teixeira, Paula; Poças, Fátima

Zinc oxide nanoparticles (ZnO NPs) have been investigated due to their distinct properties, variety of structures and sizes, and mainly for their antimicrobial activity. They have received a positive safety evaluation from the European Food Safety Authority (EFSA) for packaging applications as transparent ultraviolet (UV) light absorbers based on the absence of significant migration of zinc oxide in particulate...


Morphology of zinc oxide nanoparticles: effect on functional activity and perfo...

Mendes, Ana; Granadeiro, Carlos; Lamsaf, Hafsae; Pereira, Eulália; Teixeira, Paula; Poças, Fátima


Interaction between gold nanoparticles and blood proteins

Costa, Carlos; Cadete, João; Almeida, Miguel Peixoto de; Pereira, Eulália; Krippahlc, Ludwig; Franco, Ricardo


Nanoimmunoassays for malaria diagnosis

Gomes, Inês; Reis, Ana; Pereira, Eulália; Fortunato, Elvira; Prudêncio, Miguel; Franco, Ricardo

The development of Rapid Diagnostic Tests (RDTs) for malaria diagnosis is an area of intense research. Here, we describe two nanoimmunoassays for malaria parasite detection; one based on agarose gel electrophoresis; and another employing lab-onpaper technology. Both nanoimmunoassays use gold nanoparticles (AuNPs) functionalized with 11-mercaptoundecanoic acid (MUA) or with the pentapeptide CALNN, and further co...


Measurement of adsorption constants of laccase on gold nanoparticles to evaluat...

Peixoto de Almeida, Miguel; Quaresma, Pedro; Sousa, Susana; Couto, Cláudia; Gomes, Inês; Krippahl, Ludwig; Franco, Ricardo; Pereira, Eulália

Adsorption of enzymes to nanoparticles and the mechanisms responsible for enzyme activity modulation of adsorbed enzymes are not well understood. In this work, gold nanoparticles were used for electrostatic adsorption of a plant-derived laccase. Adsorption constants were determined by four independent techniques: dynamic light scattering, electrophoretic light scattering, agarose gel electrophoresis and fluores...


In vitro cytotoxicity of superparamagnetic iron oxide nanoparticles on neuronal...

Costa, Carla; Brandão, Fátima; Bessa, Maria João; Costa, Solange; Valdiglesias, Vanessa; Kiliç, Gözde; Fernández-Bertólez, Natalia; Quaresma, Pedro

Superparamagnetic iron oxide nanoparticles (ION) have attracted great interest for use in several biomedical fields. In general, they are considered biocompatible, but little is known of their effects on the human nervous system. The main objective of this work was to evaluate the cytotoxicity of two ION (magnetite), coated with silica and oleic acid, previously determining the possible interference of the ION ...


Controlled adsorption of cytochrome c to nanostructured gold surfaces

Gomes, Inês; Feio, Maria J.; Santos, Nuno C.; Eaton, Peter; Serro, Ana Paula; Saramago, Benilde; Pereira, Eulália; Franco, Ricardo

Controlled electrostatic physisorption of horse heart cytochrome c (Cyt c) onto nanostructured gold surfaces was investigated using Quartz-Crystal Microbalance measurements in planar gold surfaces with or without functionalization using a self-assembled monolayer (SAM) of the alkanethiol mercaptoundecanoic acid (MUA). MUA is a useful functionalization ligand for gold surfaces, shedding adsorbed biomolecules fro...


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