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Novel imidazole-based hydrazonoyl cyanides and amidrazones containing N(N,O)-he...

Fernandes, Soraia P. S.; Gonçalves, Jorge M.; Silva, Bruna F.; Pereira, Eva Q.; Coutinho, Paulo J. G.; Pereira-Wilson, Cristina; Dias, Alice

Two series of novel hybrid heterocyclic compounds that combine the imidazole ring with bioactive piperidine, morpholine or piperazine heterosystems, through a hydrazone unit, were easily obtained by two competitive pathways. Starting from 5-amino-4-cyanoformimidoyl imidazoles and 1-aminopiperidine, 4-aminomorpholine or 1-amino-4-methylpiperazine under mild acidic media led to the selective synthesis of 5-aminoi...


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