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L-Aminoacid oxidase from Bothropsleucurus Venom induces nephrotoxicity via apop...
Morais, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H.; Monteiro, Helena S. A.; Smaili, Soraya S.Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B . leucurus venom called L-aminoacid oxidase (LAAO- Bl ) was evaluated by using tubular epithelial cell lines MDCK and HK-2 and perfused kidney from rats. LAAO- Bl exhibited cytotoxicity, inducing apoptosis and necrosis in MDCK and HK-2 cell lines in a concentration-depend...
L-Aminoacid oxidase from bothrops leucurus venom Induces nephrotoxicity via apo...
Morais, Isabel C. O.; Pereira, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H. [UNESP]; Monteiro, Helena S. A.Made available in DSpace on 2015-12-07T15:33:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:53:26Z : No. of bitstreams: 1 PMC4508040.pdf: 3122617 bytes, checksum: eefcb7bc8aa0ae64a01eff72ad743fb7 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquis...