9 documents found, page 1 of 1

Epidemiology and Burden of Ventilator-Associated Pneumonia among adult intensiv...

Ventilator-associated pneumonia (VAP) is a prevailing nosocomial infection in critically ill patients requiring invasive mechanical ventilation (iMV). The impact of VAP is profound, adversely affecting patient outcomes and placing a significant burden on healthcare resources. This study assessed for the first time the contemporary VAP epidemiology in Portugal and its burden on the healthcare system and clinical...

β-Lactam Dosing in Critical Patients: A Narrative Review of Optimal Efficacy an...

Antimicrobial prescription in critically ill patients represents a complex challenge due to the difficult balance between infection treatment and toxicity prevention. Underexposure to antibiotics and therapeutic failure or, conversely, drug overexposure and toxicity may both contribute to a worse prognosis. Moreover, changes in organ perfusion and dysfunction often lead to unpredictable pharmacokinetics. In cri...

New technologies in airway management: A review

The evolution of medical knowledge and technological growth have contributed to the development of different techniques and devices for airway management. These appear to play a role in optimizing the number of attempts and overall success, ultimately reducing the negative consequences of airway manipulation. In this literature review, we highlight the recent evidence regarding new technologies applied to airwa...

β-lactam dosing in critical patients: a narrative review of optimal efficacy an...

Antimicrobial prescription in critically ill patients represents a complex challenge due to the difficult balance between infection treatment and toxicity prevention. Underexposure to antibiotics and therapeutic failure or, conversely, drug overexposure and toxicity may both contribute to a worse prognosis. Moreover, changes in organ perfusion and dysfunction often lead to unpredictable pharmacokinetics. In cri...

Optimizing Antimicrobial Drug Dosing in Critically Ill Patients

A fundamental step in the successful management of sepsis and septic shock is early empiric antimicrobial therapy. However, for this to be effective, several decisions must be addressed simultaneously: (1) antimicrobial choices should be adequate, covering the most probable pathogens; (2) they should be administered in the appropriate dose, (3) by the correct route, and (4) using the correct mode of administrat...

Pneumocephalus Following an Accidental Dural Puncture, Treated Using Hyperbaric...

Introduction: Neuraxial techniques, including epidural anaesthesia, are often used for perioperative pain control and are generally safe. However, both transient, mild and even severe, life-threatening neurologic complications can occur. Case presentation: A seventy-eight-year-old man was admitted to the hospital for a radical nephrectomy plus transurethral resection due to kidney and bladder cancer. During the...

Núcleo de inovação com personalidade jurídica própria: uma análise das modalida...

Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Programa de Pós-Graduação em Propriedade Intelectual e Transferência de Tecnologia para Inovação, Florianópolis, 2021.; A promulgação da Lei nº 13.243/16, que promoveu alterações na Lei 10.973/2004, chamada de Lei de Inovação, vigente desde 2004, permitiu aos Núcleos de Inovação Tecnológica (NITs) assumir a per...

Biofilmes Da investigação à clínica

Princípios de terapêutica antibiótica na doença crítica

RESUMO: A infeção é frequente durante a doença crítica, quer como causa da doença crítica quer como complicação da sua evolução. Paradoxalmente, os avanços da medicina moderna aumentaram eles próprios o risco de infeção, ao permitir a sobrevida até idades avançadas, ao criar um novo grupo de doentes imunodeprimidos, nomeadamente doentes tratados com fármacos que interferem com as suas defesas naturais (corticói...