2 documents found, page 1 of 1
ATP Signaling Controlling Dyskinesia Through P2X7 Receptors
Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M.Dopamine replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) is the only temporary therapy for Parkinson's disease (PD), but it triggers dyskinesia over time. Since dyskinesia is associated with increased neuronal firing that bolsters purinergic signaling, we now tested whether the selective and blood-brain barrier-permeable P2X7 receptor antagonist Brilliant Blue-G (BBG, 22.5-45 mg/kg ip) attenuated...
Histoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory ...
Caetano, Erica Pacheco; Brilhante, Raimunda S.N.; Fechine, Maria A.B.; Mesquita, Jacó R.L.; Cordeiro, Rossana A.; Rocha, Marcos F.G.; Monteiro, André J.This study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceará, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. The in vitro antifungal ...