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Diabetes and mitochondrial oxidative stress: A study using heart mitochondria f...

Santos, Dario Loureiro; Palmeira, Carlos Marques; Seiça, Raquel; Dias, José; Mesquita, José; Moreno, Antonio Joaquim; Santos, Maria Sancha

Increasing evidence shows that the overproduction of reactive oxygen species, induced by diabetic hyperglycemia, contributes to the development of several cardiopathologies. The susceptibility of diabetic hearts to oxidative stress, induced in vitro by ADP-Fe2+ in mitochondria, was studied in 12-month-old Goto-Kakizaki rats, a model of non-insulin dependent diabetes mellitus, and normal (non-diabetic) Wistar ra...

Date: 2003   |   Origin: Estudo Geral - Universidade de Coimbra
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