11 documents found, page 1 of 2
Adverse outcome pathways - development and potential regulatory application
Rossi Lima, Thania Rios [UNESP]; Souza, Nathalia Pereira de [UNESP]; Pereira, Lilian Cristina [UNESP]; Viana de Camargo, Joao Lauro [UNESP]Made available in DSpace on 2022-04-28T17:22:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Center for Evaluation of Environmental Impact on Human Health (Nucleo de Avaliacao do Impacto Ambiental sobre a Saude Humana - TOXICAM); Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil; Introduction: Over the last two decades, c...
In Vitro Apoptotic Cell Death Assessment
Pereira, Lilian Cristina [UNESP]; de Souza, Alecsandra Oliveira; Miranda, Raul Ghiraldelli; Dorta, Daniel Junqueira [UNESP]Made available in DSpace on 2021-06-25T10:50:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Chemical compounds induce cytotoxicity by various mechanisms, including interference in membrane integrity, metabolism, cellular component degradation or release, and cell division. Between the classic death pathways, namely, autophagy, apoptosis, and necrosis, apoptosis have been in the focus for the l...
Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids...
Miranda, Raul Ghiraldelli; Ferraz, Elisa Raquel Anastácio; Pereira, Lilian Cristina [UNESP]; Dorta, Daniel Junqueira [UNESP]Made available in DSpace on 2021-06-25T10:50:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; 3D Cell culture is an alternative to animal use in many drug development and toxicity studies. The 3D cell culture can mimic and reproduce the original tissue microenvironment, morphology, and mechanical and physiological characteristics, to provide a more realistic and reliable response as compared to ...
Oxidative stress monitoring in in vitro and in vivo models
Lima, Thania Rios Rossi [UNESP]; Sales, Bianca Camargo Penteado [UNESP]; Pereira, Lilian Cristina [UNESP]Made available in DSpace on 2020-12-12T02:19:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; In aerobic organisms, cellular respiration is an essential process that is divided into several steps. The third and last step is called oxidative phosphorylation, which occurs in the mitochondria, specifically in the inner mitochondrial membrane. The mitochondria are considered the cell “powerhouse” be...
Nanoparticle-mediated oxidative stress monitoring
Lima, Thania Rios Rossi [UNESP]; Nunes, Rony; Pereira, Lilian Cristina [UNESP]Made available in DSpace on 2020-12-12T02:05:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Free radicals are unstable atoms or molecules that can be not only generated under physiologic conditions but also induced by many exogenous compounds. They interact with many molecular and cellular targets and may cause adverse effects owing to oxidative stress, i.e., an imbalance between the generatio...
Do trifluralin and tebuthiuron impair isolated rat liver mitochondria?
de Oliveira, Bárbara; Pereira, Lilian Cristina [UNESP]; Pazin, Murilo; Franco-Bernanrdes, Mariana Furio; Dorta, Daniel Junqueira [UNESP]Made available in DSpace on 2020-12-12T01:48:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Universidade de São Paulo; Emerging contaminants, such as the herbicides trifluralin and tebuthiuron, comprise a class of compounds for which toxicological data are lacking, especially data regarding their harmful effects and biomarkers of exposure. Their potential damage to the environment and non-targ...
Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity
Pereira, Lilian Cristina [UNESP]; Cabral Miranda, Luiz Felipe; Franco-Bernardes, Mariana Furio; Tasso, Maria Julia; Duarte, Filipe ValenteMade available in DSpace on 2018-12-11T17:21:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade de São Paulo; Brominated flame retardants are used in consumer goods to increase product resistance to fire and/or high temperatures. Polybrominated dip...
Exposure to BDE-153 induces autophagy in HepG2 cells
Pereira, Lilian Cristina [UNESP]; Duarte, Filipe Valente; Varela, Ana Teresa Inácio Ferreira; Rolo, Anabela Pinto; Palmeira, Carlos Manuel MarquesMade available in DSpace on 2018-12-11T17:23:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Autophagy is a pro-survival process that occurs under stressful “life-threatening” conditions. This pr...
A perspective of mitochondrial dysfunction in rats treated with silver and tita...
Pereira, Lilian Cristina [UNESP]; Pazin, Murilo; Franco-Bernardes, Mariana Furio; Martins, Airton da Cunha; Barcelos, Gustavo Rafael MazzaronMade available in DSpace on 2018-12-11T17:23:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-05-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Nanotechnology is a growing branch of science that deals with the development of structural features bearing at least one dimension in the nano range. More specifically, na...
The herbicides trifluralin and tebuthiuron have no genotoxic or mutagenic poten...
Franco-Bernardes, Mariana Furio; Rocha, Otávio Pelegrino; Pereira, Lilian Cristina [UNESP]; Tasso, Maria Júlia; Meireles, GabrielaMade available in DSpace on 2018-12-11T16:49:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01; Brazil has been the largest world consumer of pesticides since 2008, followed by the USA. The herbicides trifluralin and tebuthiuron have been widely applied in agriculture. These herbicides are selective for some plant species, and their use brings various benefits. However, the genotoxic and mutagenic...