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Mapeamento do epítopo do anticorpo C3C5 da molécula de grânulo denso GRA2 de To...
Bastos, Luciana MachadoToxoplasma gondii is an obligate intracellular protozoan that belongs to the Apicomplexa phylum and causes toxoplasmosis which is especially severe in immunocompromised individuals and who acquired the infection by congenital transmission. Dense granules are organelles involved in this parasite invasion and replication of the parasite inside the cell. Among the proteins secreted by dense granules, jointly calle...
Ação in vitro da neuwiedase sobre a infecção por T. gondii em fibroblastos huma...
Bastos, Luciana MachadoCHAPTER II: The infection for T. gondii affects more than a third of the world population, affecting mainly imunocompromised individuals. Therapies in use are limited because of parasite resistance and side effects. Then, the search for new drugs to control infection is extremly important. The effects of neuwiedase, an isolated metaloprotease from Bothrops pauloensis venom, on the in vitro invasion and prolifer...
Contributions of cytogenetics to cancer research
Oliveira-Junior, Robson José de; Goulart Filho, Luiz Ricardo; Bastos, Luciana Machado; Alves, Dhiego de Deus; Silva, Sabrina Vaz dos Santos eThe two conflicting visions of tumorigenesis that are widely discussed are the gene-mutation hypothesis and the aneuploidy hypothesis. In this review we will summarize the contributions of cytogenetics in the study of cancer cells and propose a hypothetical model to explain the influence of cytogenetic events in carcinogenesis, emphasizing the role of aneuploidy. The gene mutation hypothesis states that gene-sp...