37 documents found, page 1 of 4
Insights towards the impact of subinhibitory chlorhexidine on antimicrobial sus...
Pereira, P; Almeida Santos, C; Duarte, B; Antunes, Patrícia; Peixe, L; Freitas, R; Novais, CarlaEnterococcus faecium, a human and animal commensal broadly distributed in the environment, is currently one of the most challenging multidrug-resistant (MDR) healthcare-associated pathogens worldwide. It is often exposed to chlorhexidine (CHX), a broad-spectrum antiseptic, extensively used in healthcare, domestic, and food production settings, and a diffused polluter. However, the impact of gradients of CHX con...
Seroprevalence of Protective Antibodies Against Influenza and the Reduction of ...
Guiomar, R; Pereira da Silva, S; Costa, I; Conde, P; Cristóvão, P; Rodrigues, AP; Fernandes, A; Dias, AP; Couto, AR; Ramos, A; Moita, C; Rodrigues, CBackground: Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate. Methods: We conducted an annual repeated cross-sectional seroepidemiologica...
Spontaneous Intracranial Hypotension and Multi-Level Cervical and Lumbar Epidur...
Parra, A; Relvas, F; Pereira, P; Carrilho, ASpontaneous intracranial hypotension (SIH) is a neurologic condition where the intracranial pressure is reduced due to a loss of cerebrospinal fluid from its reservoir, the intrathecal space, to surrounding tissues. It is commonly characterized by an incapacitating headache, phono-photophobia, nausea, and vomiting, commonly refractory to medical treatment and requires further investigation. We describe the case...
Can serum endoglin be used to improve the diagnostic performance in prostate ca...
Pina, F; Ferro, A; Botelho, F; Manso, M; Dias, N; Figueiredo, G; Pereira, P; Dinis, P; Barros, H; Lunet, NPurpose: New biomarkers may contribute to avoid unnecessary biopsies resulting from the suboptimal performance of prostate-specific antigen (PSA) testing. This study aimed to assess serum endoglin as a prostate cancer (PCa) diagnostic tool among biopsy candidates. Methods: A total of 262 consecutive patients referred for prostate biopsy based on abnormal digital rectal examination and/or elevated total PSA (tPS...
BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases th...
Dionísio, MR; Vieira, AF; Carvalho, R; Conde, I; Oliveira, M; Gomes, M; Pinto, MT; Pereira, P; Pimentel, J; Souza, C; Marques, MMC; Silva, VDBrain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and ...
Hematopoiesis: A Layered Organization Across Chordate Species
Elsaid, R; Soares-da-Silva, F; Peixoto, M; Amiri, D; Mackowski, N; Pereira, P; Bandeira, A; Cumano, AThe identification of distinct waves of progenitors during development, each corresponding to a specific time, space, and function, provided the basis for the concept of a “layered” organization in development. The concept of a layered hematopoiesis was established by classical embryology studies in birds and amphibians. Recent progress in generating reliable lineage tracing models together with transcriptional...
Chemoembolization of Hepatocellular Carcinoma with Drug-Eluting Polyethylene Gl...
Veloso Gomes, F; Oliveira, J; Tomé Correia, M; Costa, NV; Abrantes, J; Torres, D; Pereira, P; Ferreira, AI; Luz, JH; Spaepen, E; Bilhim, T; Coimbra, EPurpose: To evaluate the efficacy and safety of transarterial chemoembolization with polyethylene glycol (PEG) drug-eluting embolic agents in the treatment of hepatocellular carcinoma (HCC). Materials and methods: A single-center retrospective study of 302 patients (258 men; 85.4%) with HCC treated during a 20-month period was conducted. The mean patient age was 66 years ± 10; 142 (47%) had Barcelona Clinic Liv...
Western long-term accuracy of serum pepsinogen-based gastric cancer screening
Castro, C; Dinis-Ribeiro, M; Rodrigues, ANG; Calheiros, T; Santos, T; Pereira, P; Ramos, M; Cunha, H; Andrade, M; Costa, A; Sá, L; Antunes, L; Bento, MJBACKGROUND: Even though mass gastric cancer screening is controversial in Western countries, diverse strategies have been proposed in intermediate-risk to high-risk areas. AIM: The aim of this study was to determine the long-term accuracy of the pepsinogen test (PG) for early diagnosis of gastric cancer. PARTICIPANTS AND METHODS: A cohort of inhabitants from the Northern part of Portugal, aged between 40 and 74...
The inflammatory response in the regression of lumbar disc herniation
Cunha, C; Silva, A; Pereira, P; Vaz, R; Gonçalves, RM; Barbosa, MALumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, inflammation has also been indicated as the main factor responsible for LDH regression. This apparent controversy places inflammation as a good prognostic indicator of spontaneou...
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics
Watson, E; Liu, X; Thompson, R; Ripoll-Rozada, J; Wu, M; Alwis, I; Gori, A; Loh, C; Parker, B; Otting, G; Jackson, S; Pereira, P; Payne, RThe anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyrosine residues in an acidic environment that were predicted to be post-translationally sulfated in vivo. To test this prediction, insect cell expression of two anophe...