3 documents found, page 1 of 1
Biocompatibility of a self-assembled crosslinkable hyaluronic acid nanogel
Pedrosa, Sílvia Santos; Pereira, Paula Alexandra Cunha; Correia, Alexandra; Moreira, Susana; Rocha, Huho; Gama, F. M.Hyaluronic acid nanogel (HyA-AT) is a redox sensitive crosslinkable nanogel, obtained through the conjugation of a thiolated hydrophobic molecule to the hyaluronic acid chain. Engineered nanogel was studied for its biocompatibility, including immunocompatibility and hemocompatability. The nanogel did not compromise the metabolic activity or cellular membrane integrity of 3T3, microvascular endothelial cells, an...
Self-assembled nanoparticles made of fucan
Dantas-Santos, N.; Almeida-Lima, J.; Vidal, A. A. J.; Pereira, Paula Alexandra Cunha; Pedrosa, Sílvia Santos; Gama, F. M.; Rocha, H. A. O.Amphiphilic polymers can self-assemble in water due to hydrophilic and hydrophobic interactions, forming nanoparticles (NPs) with unique physicochemical characteristics and thermodynamic stability. A non toxic sulfated Fucan, extracted from Spatoglossum schroederi was chemically modified by the grafting of Hexadecylamine (C16) to the polymer hydrophilic backbone. The resulting modified material (Fucan-C16) form...
Chitosan nanoparticles for biomedical applications
Pereira, Paula Alexandra Cunha; Carvalho, Vera Maria Rego Silva; Ramos, Reinaldo Rodrigues; Gama, F. M.Chitosan is a rather abundant material with exquisite properties, which may be processed into a variety of materials including hydrogels, fibres, membranes, etc. The production of chitosan-based nanogels, also known as macromolecular miceles, has been successfully achieved using different techniques, which will be reviewed. This book covers the properties and applications of chitosan nanogels in the biomedical ...