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Multifunctional hydrogels-based therapies for chronic diabetic wound healing
Duarte, Joana; Mascarenhas-Melo, Filipa; Pires, Patrícia C.; Veiga, Francisco; Paiva-Santos, Ana CláudiaChronic diabetic wounds persist as a healthcare challenge and therefore require the use of innovative therapeutic approaches. Among emerging solutions, hydrogels stand out as a promising avenue for diabetic wound healing due to their unique properties and versatile applications, capable of addressing the complex and challenging microenvironment that characterizes such wounds. In this work, through a detailed an...
Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Develop...
Pinto, Maria Beatriz; Pires, Patrícia C.; Calhelha, Ricardo C.; Silva, Ana Rita; Sousa, Maria João; Vilas-Boas, Miguel; Falcão, Soraia; Veiga, FranciscoDespite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments lacking efficiency and leading to severe side effects. Hence, it is imperative to develop new, more efficient, and safer therapies. Bee venom has proven to have multiple and synergistic bioactivities, including antitumor effects. Nevertheless, some toxic effects have been associate...
Plant-Based Beverages: Consumption Habits, Perception and Knowledge on a Sample...
Anjos, Ofélia; Pires, Patrícia C.; Gonçalves, Joana D.; Estevinho, Leticia M.; Mendonça, António G.; Guiné, Raquel P.F.Plant-based beverages (PBB) consumption has increased significantly worldwide due to an interest in vegetarian/vegan diets, taste preferences, health and ethical and environmental issues. Therefore, this study intends to investigate consumption habits, consumer preferences and consumers’ level of knowledge about PBB. In this study, a voluntary, anonymous questionnaire survey was applied to a sample of participa...
Norcantharidin Nanoemulsion Development, Characterization, and In Vitro Antipro...
Martínez-Razo, Gabriel; Pires, Patrícia C.; Domínguez-López, María Lilia; Veiga, Francisco; Vega-López, Armando; Paiva-Santos, Ana CláudiaMelanoma is a highly lethal type of cancer that has had an increase in incidence in the last decades. Nevertheless, current therapies lack effectiveness and have highly disabling side effects, which calls for new therapeutic strategies. Norcantharidin (NCTD) is an acid derivative with potential antitumor activity isolated from natural blister beetles. However, its solubility limitations restrict its use. To add...
In Vitro Models for Anti-Aging Efficacy Assessment: A Critical Update in Dermoc...
Cruz, Ana M.; Gonçalves, Margarida C.; Marques, Matilde S.; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.The skin is the human body’s largest organ and serves as a crucial boundary between the body and the external environment. As a natural process, skin aging cannot be avoided, and it causes changes in the skin’s strength, structure, elasticity, and integrity. Many approaches have been developed over the years to study the skin, including in vivo and in vitro methods. Nevertheless, animal assays have ethical issu...
Nanomaterials in Cosmetics: An Outlook for European Regulatory Requirements and...
Ferreira, Laura; Pires, Patrícia C.; Fonseca, Mariana; Costa, Gustavo; Giram, Prabhanjan Shridhar; Mazzola, Priscila Gava; Bell, VictoriaThe use of materials and products that improve appearance and provide comfort and well-being goes back to the beginning of civilization. Cosmetics is an evolving market that has increasingly focused on innovative technological approaches. Nanotechnology is one of the most revolutionary and promising fields for the development of novel and enhanced cosmetic products, owing to the remarkable multifunctional chara...
Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update...
Antunes, Jéssica; Amado, Joana; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.Depression and anxiety are high incidence and debilitating psychiatric disorders, usually treated by antidepressant or anxiolytic drug administration, respectively. Nevertheless, treatment is usually given through the oral route, but the low permeability of the blood-brain barrier reduces the amount of drug that will be able to reach it, thus consequently reducing the therapeutic efficacy. Which is why it is im...
Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most P...
Ferreira, Maria Daniela; Duarte, Joana; Veiga, Francisco; Paiva-Santos, Ana Cláudia; Pires, Patrícia C.Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions jeopardize clinical outcomes, resulting in patient non-compliance. The design formulation strategies for enhancing brain drug delivery has been a major challenge, mainly due to the restrictive properties of the blood-brain barrier. However...
Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2...
Badalkhani, Omolbanin; Pires, Patrícia C.; Mohammadi, Maryam; Babaie, Soraya; Paiva-Santos, Ana Cláudia; Hamishehkar, HamedThe human skin is a recurring target of external aggressions, such as UV radiation, leading to exacerbation of the aging process and the occurrence of skin diseases, such as cancer. Hence, preventive measures should be taken to protect it against these aggressions, consequently decreasing the chance of disease development. In the present study, a topical xanthan gum nanogel containing gamma-oryzanol-loaded nano...
Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerat...
Pires, Patrícia C.; Paiva-Santos, Ana Cláudia; Veiga, FranciscoPsychiatric and neurodegenerative disorders are amongst the most prevalent and debilitating diseases, but current treatments either have low success rates, greatly due to the low permeability of the blood-brain barrier, and/or are connected to severe side effects. Hence, new strategies are extremely important, and here is where liposome-derived nanosystems come in. Niosomes, transfersomes, and ethosomes are nan...