6 documents found, page 1 of 1

Transcriptional profile and structural conservation of SUMO-Specific proteases ...

Small ubiquitin-related modifier (SUMO) is involved in numerous cellular processes including protein localization, transcription, and cell cycle control. SUMOylation is a dynamic process, catalyzed by three SUMO-specific enzymes and reversed by Sentrin/SUMO-specific proteases (SENPs). Here we report the characterization of these proteases in Schistosoma mansoni. Using in silico analysis, we identified two SENPs...

Medicamentos anti-hipertensivos utilizados na área rural de Ouro Preto, MG.

Conservation and developmental expression of ubiquitin isopeptidases in Schisto...

Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiq¬uitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an im¬portant role in Ub-dependent processes, little is known about their role in ...

NEDD8 conjugation in Schistosoma mansoni : genome analysis and expression profi...

NEDD8 is an ubiquitin-like molecule that covalently binds to target proteins through an enzymatic cascade analogous to ubiquitylation. This modifier is known to bind to p53 and p73, as well as all Cullin family proteins, which are essential components of Skp1/Cul-1/F-box protein (SCF)-like Ub ligase complexes. Here, we focused on a genomic analysis of the genes involved in the NEDD8 conjugation pathway in Schis...

Characterisation of major vault protein during the life cycle of the human para...

Vaults are ribonucleoproteins (13MDa) highly conserved among lower and higher eukaryotes. Their association produces a complex composed of three proteins named Major Vault Protein (MVP), vault (PolyADP-ribose) polymerase (VPARP) and Telomerase-associated protein (TEP1), plus a small untranslated RNA. The exact function of this complex is unknown, although the biological role of vaults has been associated with m...

Modificação pós-traducional dependente de SUMO em Schistosoma mansoni : padrão ...

A conjugação de SUMO aos substatos alvo ocorre através de um mecanismo análogo ao da ubiquitina, pela ação sequencial de três classes de enzimas: E1 ativadora (Aos1-Uba2), E2 conjugadora (Ubc9) e E3 ligases (PIAS, Polycomb2 e RanBP2). SUMO é sintetizada como um precursor inativo, que requer processamento por proteases específicas (SENPs). A conjugação de SUMO é uma modificação reversível e transitória. As mesma...