3 documents found, page 1 of 1
Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant M...
Santos, João Campos; Marques, Carla Cruz; Baptista, Maria Conceição; Pimenta, Jorge; Teixeira, José; Montezinho, Liliana; Cagide, FernandoSperm cells are particularly vulnerable to reactive oxygen species (ROS), impairing their fertilizing ability. Our objective was to study the effect of a novel mitochondrial-directed antioxidant, AntiOxBEN2, on bovine sperm function. This antioxidant was added to the semen capacitation medium (CAP), during the swim-up process, and to the fertilization medium (FERT) during the co-incubation of matured oocytes an...
Medical grade honey as a promising treatment to improve ovarian tissue transpla...
Azevedo, Ana Rita; Pais, Ana Sofia; Almeida-Santos, Teresa; Pires, Virgínia M. R.; Pessa, Pedro; Marques, Carla C.; Nolasco, SofiaOvarian tissue cryopreservation is a female fertility preservation technique that presents major challenges for the maintenance of follicular viability after transplantation. The aim of this study was to evaluate and compare the application of L-Mesitran Soft(R), a product containing 40% medical grade honey (MGH), with other strategies to improve ovarian grafts' viability. For this purpose, bovine ovarian tissu...
Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro
Fonseca, Élisa; Marques, Carla Cruz; Pimenta, Jorge; Jorge, Joana; Baptista, Maria Conceição; Gonçalves, Ana Cristina; Pereira, Rosa M. L. N.Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested. Urolithin A (UA) is a natural metabolite with pro-apoptotic and antioxidant effects, capable of preventing the accumulation of dysfunctional mitochondria in different aged cells. UA has never been tested in bovine oocytes. Our aim was to st...