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Multidrug resistance assessment of indoor air in Portuguese long-term and acute...
Santos-Marques, C.; Teixeira, C.; Pinheiro, R.; Brück, W. M.; Pereira, Sónia Gonçalves; dos Santos Marques, Catarina; Silva Teixeira, CamilaBackground: Knowledge about air as a pool of pathogens and multidrug resistance (MDR) in healthcare units apart from hospitals is scarce. Aim: To investigate these features in a Portuguese long-term healthcare unit (LTHU) and a central hospital (CH). Methods: Air samples were collected and their microbial load (bacteria and fungi) determined. Bacterial isolates were randomly selected for further characterizatio...
Celiac disease gut microbiome studies in the third millennium: reviewing the fi...
Luz, Vanessa C. C.; Pereira, Sónia GonçalvesCeliac disease is an autoimmune enteropathy caused by the ingestion of minute amounts of gluten in a subset of genetically predisposed individuals. Its onset occurs at different ages and with variable symptoms. The gut microbiome may contribute to this variability. This review aims to provide an overview of the available research on celiac disease gut microbiome and identify the knowledge gap that could guide f...
Dietary patterns drive loss of fiber-foraging species in the celiac disease pat...
Roque, Ana; Zanker, Joyce; Brígido, Sara; Tomaz, Maria Beatriz; Gonçalves, André; Barbeiro, Sandra; Benítez-Páez, Alfonso; Pereira, Sónia GonçalvesBackground Celiac disease is an autoimmune disorder triggered by dietary gluten in genetically predisposed indi‑viduals that primarily afects the small intestine. Studies have reported diferentially abundant bacterial taxa in the gut microbiota of celiac patients compared with non-celiac controls. However, fndings across studies have inconsisten‑cies and no microbial signature of celiac disease has been defned ...
Bacteria: Potential Make-or-Break Determinants of Celiac Disease
Roque, Ana; Pereira, Sónia GonçalvesCeliac disease is an autoimmune disease triggered by dietary gluten in genetically susceptible individuals that primarily affects the small intestinal mucosa. The sole treatment is a gluten-free diet that places a social and economic burden on patients and fails, in some, to lead to symptomatic or mucosal healing. Thus, an alternative treatment has long been sought after. Clinical studies on celiac disease have...
Patterns of Medication Management and Associated Medical and Clinical Features ...
Dixe, Maria dos Anjos; Pinho, Joana; Pereira, Filipa; Verloo, Henk; Meyer-Massetti, Carla; Pereira, Sónia GonçalvesAgeing is frequently associated with multimorbidity and polypharmacy. The present study aimed to identify the current medication management patterns and the profiles of homedwelling older adults and to find any association with their conditions, including frailty and cognitive impairment. Within the scope of this cross-sectional study, 112 older adults living in the community were assessed via face-to-face stru...
An Intervention Program to Reduce Medication-Related Problems Among Polymedicat...
Pereira, Filipa; Dixe, Maria dos Anjos; Pereira, Sónia Gonçalves; Meyer-Massetti, Carla; Verloo, HenkBackground: Effective medication management is one of the essential preconditions for enabling polymedicated home-dwelling older adults with multiple chronic conditions to remain at home and preserve their quality of life and autonomy. Lack of effective medication management predisposes older adults to medication-related problems (MRPs) and adverse health outcomes, which can lead to the degradation of a patient...
Modulation of gut microbiota by diet and probiotics: potential approaches to pr...
Cruz, Marisa Carreira; Azinheiro, Sarah; Pereira, Sónia GonçalvesGestational diabetes mellitus (GDM) is a rising global health problem that affects approximately 6% of pregnant women. Lifestyle interventions, particularly diet, and exercise are the first-line treatment, followed by pharmacotherapy, but with associated side effects to both mother and offspring. Modulation of gut microbiota may help prevent or manage GDM. Some gut bacterial groups associated with GDM are also ...
Detection of Patients at Risk of Multidrug-Resistant Enterobacteriaceae Infecti...
Gouareb, Racha; Bornet, Alban; Proios, Dimitrios; Pereira, Sónia Gonçalves; Teodoro, DouglasBackground: While Enterobacteriaceae bacteria are commonly found in the healthy human gut, their colonization of other body parts can potentially evolve into serious infections and health threats. We investigate a graph-based machine learning model to predict risks of inpatient colonization by multidrug-resistant (MDR) Enterobacteriaceae. Methods: Colonization prediction was defined as a binary task, where the ...
The role of pseudocereals in celiac disease: reducing nutritional deficiencies ...
Caeiro, Carolina; Pragosa, Caroline; Carreira Cruz, Marisa; Pereira, Cidália; Pereira, Sónia GonçalvesCeliac disease or gluten-dependent enteropathy is a chronic autoimmune pathology triggered by dietary gluten in genetic predisposed individuals, mediated by transglutaminase 2 IgA autoantibodies and associated with a deteriorating immune and inflammatory response. ,is leads to intestinal villous atrophy, impairing the intestinal mucosa structure and function of secretion, digestion, and absorption. ,e result is...
Infection prevention and control strategies against carbapenem resistant Entero...
Santos-Marques, Catarina; Ferreira, Helena; Pereira, Sónia GonçalvesBackground: Antimicrobial resistance is exponentially worsening, and the spread of prevalent carbapenem resistant Enterobacteriaceae (CRE) is a major contributor to this global concern. Infection prevention and control strategies are increasingly consolidated key tools to control this worldwide problem. Aim: To identify, collect and analyse available evidence regarding the impact of infection prevention and con...