7 documents found, page 1 of 1
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67...
Oliveira, Sofia B.; Machado, Mariana Q.; Sousa, Diana; Pereira, Sofia S.; Pignatelli, DuarteDistinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear malignant potential based on the histopathological features comprised of the Weiss score. Previous studies reported the potential utility of immunohistochemistry (IHC) markers to recognize malignancy, in particular the Insulin-like growth factor 2 (IGF2) and the proliferation marker, Ki-67. ...
Colon tumor CD31 expression is associated with higher disease-free survival in ...
Silva, Ana; Pereira, Sofia S.; Brandão, José Ricardo; Brochado, Paulo; Monteiro, Mariana P.; Araújo, António; Faria, GilMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most...
Effect of metabolic syndrome and individual components on colon cancer characte...
Silva, Ana; Pereira, Sofia S.; Monteiro, Mariana P.; Araújo, António; Faria, GilMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, whether the cluster of metabolic changes that define MS also influence CC prognosis remains unclear. Thus, our aim was to investigate whether the presence of MS or any of the MS individual components could provide prognostic information on tumor phenotype and survival outcomes. Clinical and pathological data from patients wit...
High-intensity infrasound effects on glucose metabolism in rats
Pereira, Gonçalo Martins; Santos, Madalena; Pereira, Sofia S.; Borrecho, Gonçalo; Tortosa, Francisco; Brito, José; Freitas, DiamantinoRecent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar...
Effects of high-intensity infrasound on liver lipid content of rats
Pereira, Gonçalo Martins; Pereira, Sofia S.; Santos, Madalena; Brito, José; Freitas, Diamantino; Carvalho, António Oliveira de; Águas, ArturPrevious experimental studies show that exposure to noise with high and audible frequencies causes multiple metabolic alterations, such as increased liver glycogen and triglycerides. However, the effect of exposure to sound with lower frequencies, such as high-intensity infrasound (frequency <20 Hz and sound pressure level >90 dB), on the liver lipid content is still unclear. As such, we aimed to study the effe...
HEPATIC CELL PROLIFERATION PEAKS ONE WEEK AFTER PORTAL VEIN LIGATION AND IS NOT...
Guimarães, Marta; Morais, Tiago; Pereira, Sofia S.; Monteiro, Ana; Vilaça, Ana; Ferreira, Tiago; Castro, Tiago; Rodrigues, Pedro; Oliveira, VeraIntroduction: Selective portal vein ligation is currently used to induce hypertrophy of healthy liver segments before partial hepatectomy performed to treat metastatic or primary liver cancer. A major limitation of this procedure is the time interval needed between the portal ligation and hepatic resection, potentially leading to tumour progression. We report the characterization of the liver regeneration kinet...
Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells
Moreira, Ângela; Pereira, Sofia S.; Costa, Madalena; Morais, Tiago; Pinto, Ana; Fernandes, Rúben; Monteiro, Mariana P.Obesity has been associated with increased incidence and risk of mortality of prostate cancer. One of the proposed mechanisms underlying this risk association is the change in adipokines expression that could promote the development and progression of the prostate tumor cells. The main goal of this study was to evaluate the effect of preadipocyte and adipocyte secretome in the proliferation, migration and invas...