Sporotrichosis, a fungal infection caused by dimorphic fungi belonging to the genus Sporothrix, is the most prevalent subcutaneous mycosis in the world. In addition to the limited pharmacological arsenal for the treatment of this disease, recent studies have shown that Sporothrix spp. it is capable of forming biofilms, a structure classically associated with increased tolerance to antifungals. Thus, terpinen-4-...
Sporotrichosis is a subcutaneous disease caused by dimorphic fungi belonging to the Sporothrixschenckii complex. This disease can mimic several other diseases of dermatological involvement, among them leishmaniasis. Differential diagnosis between these diseases may be a challenge and misdiagnosis can lead patients with sporotrichosis treated with leishmanicidal drugs. The aim of this study was to evaluate the a...
Biossurfactantes são compostos anfifílicos que atuam como moléculas importantes para os processos interfaciais, condicionando a superfície celular microbiana e assim, apresentando ampla atividade antimicrobiana. Essa pesquisa investigou o efeito de um biossurfactante produzido por Bacillus spp., sobre a integridade da membrana de cepas de Trichosporon asahii (n=3) e T. inkin (n=1). Frações enriquecidas com bios...
It is well known that prolonged antibiotic therapy alters the mucosal microbiota composition, increasing the risk of invasive fungal infection (IFI) in immunocompromised patients. The present study investigated the direct effect of b-lactam antibiotics cefepime (CEF) and amoxicillin (AMOX) on biofilm production by Candida albicans ATCC 10231. Antibacterials at the peak plasmatic concentration of each drug were ...
Moringa oleifera Lam (Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for the...