5 documents found, page 1 of 1
Nuclear Magnetic Resonance (NMR), Infrared (IR) and Mass Spectrometry (MS) stud...
Pereira, Wagner Luiz; Pires, Diego Arantes Teixeira; Teixeira, Róbson Ricardo; Figueroa-Villar, José Daniel; Nascimento, Claudia Jorge doThe keto-enol tautomerism of 3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohexen-1-yl)isobenzofuran- 1(3H-one (1), 3-(2-hydroxy-6-oxocyclohex-1-enyl)isobenzofuran-1(3H)-one (2), 3-(2- hydroxy- 4-methyl-6-oxocyclohex-1-enyl)isobenzofuran-1(3H)-one (3), 3-(2-hydroxy-5-oxocyclopent-1-enyl) isobenzofuran-1(3H)-one (4) and 2-(3-oxo-1,3-dihydroisobenzofuran-1-yl)-1H-indene-1,3(2H)-dione (5) were investigated. We noticed that ...
Síntese de isobenzofuranonas e indan-1,3-dionas: aspectos estruturais e avaliaç...
Pereira, Wagner LuizCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; O presente trabalho objetivou a síntese e a avaliação das atividades citotóxica e inibitória da protease NS2B-NS3 de um grupo de isobenzofuranonas e indan-1,3-dionas contendo porções triazólicas em suas estruturas. Na Parte I do trabalho, descreve-se a síntese de treze isobenzofuranonas e treze indan-1,3-dionas contendo porções triazólicas. Os compost...
The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against L...
Pereira, Wagner Luiz; Vasconcellos, Raphael de Souza; Mariotini-Moura, Christiane; Gomes, Rodrigo Saar; Firmino, Rafaela de CássiaLeishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expe...
Synthesis and antiproliferative activity of C-3 functionalized Isobenzofuran-1(...
Teixeira, Róbson Ricardo; Bressan, Gustavo Costa; Pereira, Wagner Luiz; Ferreira, Joana Gasperazzo; Oliveira, Fabrício Marques deA series of thirteen C-3 functionalized isobenzofuran-1(3H)-ones (phtalides) was synthesized via condensation, aromatization, and acetylation reactions. NMR (one and two dimensional experiments), IR, and mass spectrometry analysis allowed confirmation of the identity of the synthesized compounds. The substances were submitted to in vitro bioassays against U937 (lymphoma) and K562 (myeloid leukemia) cancer cell ...
Síntese e avaliação das atividades fitotóxica e antiproliferativa de isobenzofu...
Pereira, Wagner LuizConselho Nacional de Desenvolvimento Científico e Tecnológico; The present investigation aimed to synthesize a series of isobenzofuran-1(3H)-ones (phtalides) structurally similar to the secondary metabolite cryphonectric acid. The substances were prepared via condensation, aromatization and acetylation reactions. The identity of the synthesized compounds were confirmed based on IR, 1H and 13C NMR (1D), HMBC and...