38 documents found, page 1 of 4
Prognostic features of sarcoidosis course in a Brazilian cohort
Castro,Marina Dornfeld Cunha; Pereira,Carlos Alberto de Castro; Soares,Maria RaquelABSTRACT Objective: To identify predictive features associated with the course of sarcoidosis at initial evaluation and to develop a predictive score. Methods: This was a retrospective study involving pulmonary sarcoidosis patients, classified as having a self-limited or persistent course of disease, comparing data between the outcomes by univariate analysis. Features related to persistent disease were selected...
Carbohydrate antigen 15-3 as a marker of disease severity in patients with chro...
Gomes,Paula Silva; Soares,Maria Raquel; Marchenta,Maria Fernanda Munhoz Lages; Meirelles,Gustavo de Souza Portes; Ferreira,Rimarcs GomesABSTRACT Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases. Our aim was to determine whether CA 15-3 could be considered a biomarker of disease severity in patients with chronic hypersensitivity pneumonitis (cHP). Methods: This was a prospective observational study involving adult patients with cH...
Reference values for pulmonary volumes by plethysmography in a Brazilian sample...
Lessa,Thamine; Pereira,Carlos Alberto de Castro; Soares,Maria Raquel; Matos,Renato; Guimarães,Virgínia Pacheco; Sanches,Giancarlo; Rassi,Roberto HelouABSTRACT Objective: To derive reference values for healthy white Brazilian adults who have never smoked and to compare the obtained values with reference values derived by Crapo and by Neder. Methods: Reference equations by quantile regressions were derived in 122 men and 122 women, non-obese, living in seven cities in Brazil. Age ranged from 21 to 92 years in women and from 25 to 88 years in men. Lung function...
Segurança e tolerabilidade de Nintedanibe em pacientes com fibrose pulmonar idi...
Pereira,Carlos Alberto de Castro; Baddini-Martinez,José Antonio; Baldi,Bruno Guedes; Jezler,Sérgio Fernandes de Oliveira; Rubin,Adalberto SperbRESUMO Objetivo Ensaios clínicos mostraram que 150 mg de Nintedanibe duas vezes ao dia reduzem a progressão da doença em pacientes com Fibrose Pulmonar Idiopática (FPI), com um perfil de efeitos adversos que é controlável para a maioria dos pacientes. Antes da aprovação do Nintedanibe como tratamento para a FPI no Brasil, um Programa de Acesso Expandido (PEA) foi iniciado para fornecer acesso precoce ao tratame...
Valores de referência para a difusão do monóxido de carbono (fator de transferê...
Guimarães,Virgínia Pacheco; Miranda,Débora Marques de; Reis,Marco Antônio Soares; Andrade,Thamine Lessa; Matos,Renato Lopes; Soares,Maria RaquelRESUMO Objetivo Derivar valores de referência em adultos brancos para a difusão do monóxido de carbono (DCO) em uma amostra de diferentes locais do Brasil por um mesmo modelo de equipamento (Sensormedics) e comparar os resultados com os derivados pelas equações de Crapo, Miller e Neder, e da proposta pelo Global Lung Initiative (GLI). Métodos Os testes foram realizados de acordo com as normas sugeridas pela ATS...
Six-minute walk distance and survival time in patients with idiopathic pulmonar...
Mancuzo,Eliane Viana; Soares,Maria Raquel; Pereira,Carlos Alberto de CastroABSTRACT Objective: To determine the cut-off point for the six-minute walk distance (6MWD) that indicates lower survival time in patients with idiopathic pulmonary fibrosis (IPF) in Brazil. Methods: This was retrospective study carried out in two referral centers for IPF. The 6MWT was performed twice, considering the highest value of the 6MWD. Various cut-off points were estimated, in absolute values and in per...
Spirometry reference values for Black adults in Brazil
Prata,Tarciane Aline; Mancuzo,Eliane; Pereira,Carlos Alberto de Castro; Miranda,Silvana Spíndola de; Sadigursky,Larissa Voss; Hirotsu,CamilaABSTRACT Objective: To derive reference equations for spirometry in healthy Black adult never smokers in Brazil, comparing them with those published in 2007 for White adults in the country. Methods: The examinations followed the standards recommended by the Brazilian Thoracic Association, and the spirometers employed met the technical requirements set forth in the guidelines of the American Thoracic Society/Eur...
Granulomatous intersticial nephritis secondary to sarcoidosis
Piraciaba,Tamires Teixeira; Balda,Carlos Alberto; Moura,Luiz Antônio Ribeiro de; Pereira,Carlos Alberto de Castro; Kirsztajn,Gianna MastroianniABSTRACT Introduction: Granulomatous interstitial nephritis is a rare condition, in which renal involvement is uncommon. Its etiology is variable, and may be medicinal, infectious or inflammatory origin. Case report: This is a 65-year-old male patient with renal lesions of unknown etiology, associated with hypercalcaemia. During the investigation, cardiac insufficiency with diastolic dysfunction and interstitia...
Pleuroparenchymal fibroelastosis: report of two cases in Brazil
Gomes,Paula Silva; Shiang,Christina; Szarf,Gilberto; Coletta,Ester Nei Aparecida Martins; Pereira,Carlos Alberto de CastroABSTRACT Pleuroparenchymal fibroelastosis (PPFE) is a rare lung disease. It can be idiopathic or associated with any one of various conditions. To our knowledge, this is the first report of two cases of PPFE in Brazil. Our first patient presented with pleural and subpleural fibrosis in the upper lobes; a spiculated nodule in the left upper lobe; and a mild reticular pattern in the lower lobes. Surgical lung bio...
Bronchodilator response cut-off points and FEV 0.75 reference values for spirom...
Burity,Edjane Figueiredo; Pereira,Carlos Alberto de Castro; Jones,Marcus Herbert; Sayão,Larissa Bouwman; Andrade,Armèle Dornelas deABSTRACT Objective: To determine the cut-off points for FEV1, FEV0.75, FEV0.5, and FEF25-75% bronchodilator responses in healthy preschool children and to generate reference values for FEV0.75. Methods: This was a cross-sectional community-based study involving children 3-5 years of age. Healthy preschool children were selected by a standardized questionnaire. Spirometry was performed before and after bronchodi...