8 documents found, page 1 of 1
How IT Governance can assist IoT project implementation
Henriques, David; Pereira, Ruben; Bianchi, Isaías S.; Almeida, Rafael; Silva, Miguel Mira daInternet of things (IoT) is considered a key technology for the Industry 4.0 revolution. Information Technology (IT) governance (ITG) is now an increasingly important tool for organizations to align their IT strategy and infrastructures with the organizations’ business objectives. The most adopted ITG framework is COBIT, which defines seven enabler categories. These enablers aim to facilitate the implementation...
How IT Governance can assist IoT project implementation
Henriques, David; Pereira, Ruben; Bianchi, Isaías S.; Almeida, Rafael; Silva, Miguel Mira daInternet of things (IoT) is considered a key technology for the Industry 4.0 revolution. Information Technology (IT) governance (ITG) is now an increasingly important tool for organizations to align their IT strategy and infrastructures with the organizations’ business objectives. The most adopted ITG framework is COBIT, which defines seven enabler categories. These enablers aim to facilitate the implementation...
Data-driven reverse engineering of signaling pathways using ensembles of dynami...
Henriques, David; Villaverde, Alejandro F.; Rocha, Miguel; Saez-Rodriguez, Julio; Banga, Julio R.Signaling pathways play a key role in complex diseases such as cancer, for which the development of novel therapies is a difficult, expensive and laborious task. Computational models that can predict the effect of a new combination of drugs without having to test it experimentally can help in accelerating this process. In particular, network-based dynamic models of these pathways hold promise to both understand...
Formulação da Teoria Generalizada de Vigas para calcular cargas de bifurcação l...
Henriques, David; Gonçalves, Rodrigo; Camotim, DinarApresenta-se um elemento finito baseado na Teoria Generalizada de Vigas (ou GBT, Generalized Beam Theory) para calcular, com eficiência computacional e precisão, cargas de bifurcação laterais-distorcionais em vigas mistas aço-betão. A determinação das cargas de bifurcação é realizada em duas etapas: (i) uma análise de pré-encurvadura, que contabiliza os efeitos de shear lag e da fendilhação do betão, e (ii) uma...
Recent Developments in the GBT-Based Numerical Modeling of Steel-Concrete Compo...
Gonçalves, Rodrigo; Henriques, David; Camotim, DinarThis paper presents the latest developments concerning the numerical modeling ofsteel-concrete composite beams using GBT-based (beam) finite elements. In particular, it is shown that GBT makes it possible to assess, accurately and with computational efficiency, the buckling (bifurcation) behavior of steel-concrete composite beams subjected to negative (hogging) bending. Two relevant buckling phenomena are consi...
Reverse engineering of logic-based differential equation models using a mixed-i...
Henriques, David; Rocha, Miguel; Saez-Rodriguez, Julio; Banga, Julio R.Motivation: Systems biology models can be used to test new hypotheses formulated on the basis of previous knowledge or new experimental data, contradictory with a previously existing model. New hypotheses often come in the shape of a set of possible regulatory mechanisms. This search is usually not limited to finding a single regulation link, but rather a combination of links subject to great uncertainty or no ...
An efficient non-linear GBT-based finite element for steel-concrete beams
Henriques, David; Gonçalves, Rodrigo; Camotim, DinarA computationally efficient GBT based beam finite element is presented, specifically developed for capturing the materially non-linear behaviour of wide flange steel concrete composite beams. The element incorporates shear lag effects, as well as concrete and steel non-linear material behaviour Analytical solutions for elastic shear lag problems are de rived and a set of materially linear and non-linear numeric...
Um elemento finito fisicamente não-linear para vigas mistas aço-betão
Henriques, DavidDissertação para obtenção do Grau de Mestre em Engenharia Civil; Neste trabalho desenvolve-se, implementa-se e valida-se um elemento finito de barra baseado na Teoria Generalizada de Vigas, capaz de caracterizar eficazmente o comportamento fisicamente não-linear global de vigas mistas aço-betão. O elemento finito considera os seguintes efeitos: (i) shear lag, (ii) deformação por esforço transverso da alma do pe...