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Enzyme kinetics, structural analysis and molecular modeling studies on a series...
Postigo,Matheus P; Krogh,Renata; Terni,Marcela F; Pereira,Humberto M; Oliva,Glaucius; Castilho,Marcelo S; Andricopulo,Adriano DThe enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the development of novel drugs against schistosomiasis, a neglected tropical disease that affects about 200 million people worldwide. In the present work, enzyme kinetic studies were carried out in order to determine the potency and mechanism of inhibition of a series of SmPNP inhibitors. In additio...
Date: 2011
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Origin: Oasisbr