Ovarian hyperstimulation syndrome (OHSS) can be a serious condition. There are very few cases described of massive vulvar edema in OHSS. Ovarian hyperstimulation can also have an important impact on thyroid function. We present a case of severe OHSS, massive vulvar edema and severe thyroid dysfunction in a young woman with a congenital hypothyroidism submitted to a second IVF cycle for anovulation. The particul...