3 documents found, page 1 of 1
Pro-inflammatory polarization and colorectal cancer modulate alternative and in...
Wilton, J; Mendonça, FL; Pereira-Castro, I; Tellier, M; Nojima, T; Costa, AM; Freitas, J; Murphy, S; Oliveira, MJ; Proudfoot, NJ; Moreira, AMacrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3'UTR (3'UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, in particular in cancer and activated immune cells. Yet, how polarization and colorectal cancer (CRC) cells microenvironment affect 3'UTR-APA and IPA in...
Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Med...
Cruz, R; Pereira-Castro, I; Almeida, MT; Moreira, A; Cabanes, D; Sousa, SThe host cytoskeleton is a major target for bacterial pathogens during infection. In particular, pathogens usurp the actin cytoskeleton function to strongly adhere to the host cell surface, to induce plasma membrane remodeling allowing invasion and to spread from cell to cell and disseminate to the whole organism. Keratins are cytoskeletal proteins that are the major components of intermediate filaments in epit...
Thymic epithelial cells require p53 to support their long-term function in thym...
Rodrigues, PM; Ribeiro, AR; Perrod, C; Landry, JJM; Araújo, L; Pereira-Castro, I; Benes, V; Moreira, A; Xavier-Ferreira, H; Meireles, C; Alves, NLThymic epithelial cells (TECs) provide crucial microenvironments for T-cell development and tolerance induction. As the regular function of the thymus declines with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo. Beyond its recognized tumor suppressive function, p53 controls several immunoregulatory pathways. To study the cell-autonomous role o...