12 documents found, page 1 of 2
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Pérez, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C.; Frazão, Laura P.; Peixoto, Carolina; Cubells, AlmudenaPublisher Copyright: © 2025 by the authors.; Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable ...
Analytical validation and algorithm improvement of HepatoPredict kit to assess ...
Gonçalves-Reis, Maria; Proença, Daniela; Frazão, Laura P.; Neto, João L.; Silva, Sílvia; Pinto-Marques, Hugo; Pereira-Leal, José; Cardoso, JoanaFunding Information: The authors wish to thank to the European Innovation Council for having partially financed this work with a grant under the EIC Accelerator scheme (Contract Nº946364). The authors also thank the patients, Neuralshift, and the pathology team from the Curry Cabral Hospital headed by António Figueiredo, with a special mention to Clara Rodrigues. Moreover, the authors particularly acknowledge t...
BRCA1 VUS
Lourenço, Rita Adubeiro; Lança, Miguel; Monteiro Gil, Octávia; Cardoso, Joana; Lourenço, Teresa; Pereira-Leal, José; Rodrigues, António SebastiãoGenetic testing for susceptibility genes through next‑generation sequencing (NGS) has become a widely used technique. Using this, a number of genetic variants have been identified, several of which are variants of unknown significance (VUS). These VUS can either be pathogenic or benign. However, since their biological effect remains unclear, functional assays are required to classify their functional nature. As...
A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liv...
Pinto-Marques, Hugo; Cardoso, Joana; Silva, Sílvia; Neto, João L; Gonçalves-Reis, Maria; Proença, Daniela; Mesquita, Marta; Manso, André; Carapeta, SaraCopyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.; OBJECTIVE: To propose a new decision algorithm combining biomarkers measured in a tumor biopsy with clinical variables, to predict recurrence after liver transplantation (LT). SUMMARY BACKGROUND DATA: Liver cancer is one of the most frequent causes of cancer-related mortality. LT is the best treatment for hepatocellular carcinoma (HCC) pa...
Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota
Marques, Cláudia; Dinis, Liliana; Barreiros Mota, Inês; Morais, Juliana; Ismael, Shámila; Pereira-Leal, José; Cardoso, Joana; Ribeiro, PedroFunding This work was supported by ERDF through the operation POCI-01−0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização − COMPETE2020 and by FCT - Fundação para a Ciência e a Tecnologia, IP national support through CINTESIS, R&D Unit (UIDB/4255/2020), CHRC (UIDP/04923/2020 and UIDB/04923/2020) and through the project reference PTDC/BAA-AGR/7419/2020.; Gut microbiota m...
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes
Ismael, Shámila; Silvestre, Marta P.; Vasques, Miguel; Araújo, João R.; Morais, Juliana; Duarte, Maria Inês; Pestana, Diogo; Faria, AnaFunding: This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and CHRC (UIDB/04923/2020 and UIDP/04923/2020). This study was also supported by Emilio Peres grant from the Portugu...
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Sever...
Moreira-Rosário, André; Marques, Cláudia; Pinheiro, Hélder; Araújo, João Ricardo; Ribeiro, Pedro; Rocha, Rita; Mota, Inês; Pestana, Diogo; Ribeiro, RitaFunding Information: We acknowledge support from the NOVA Medical School of Universidade NOVA de Lisboa, CINTESIS, and CHRC. Funding. This study was sponsored by the Funda??o para a Ci?ncia e a Tecnologia (FCT, project no. 268_596883842), BIOCODEX, and CINTESIS (reference UIDB/4255/2020). The funders had no role in study design, data collection, data analysis, data interpretation, or manuscript writing. Publish...
Genetic competence drives genome diversity in Bacillus subtilis
Brito, Patrícia H; Chevreux, Bastien; Serra, Cláudia R; Schyns, Ghislain; Henriques, Adriano O; Pereira-Leal, José© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.; Prokaryote genomes are the result of a dynamic flux of genes, with increases achieved via horizontal gene transfer and reductions occurring through gene loss. The ecological and selective forces that drive this genomic flexibility vary across species. Bacillus subtilis is a naturally compete...
Hope for GWAS: Relevant Risk Genes Uncovered from GWAS Statistical Noise
Correia, Catarina; Diekmann, Yoan; Vicente, Astrid; Pereira-Leal, JoséHundreds of genetic variants have been associated to common diseases through genome-wide association studies (GWAS), yet there are limits to current approaches in detecting true small effect risk variants against a background of false positive findings. Here we addressed the missing heritability problem, aiming to test whether there are indeed risk variants within GWAS statistical noise and to develop a systema...
Hope for GWAS: Relevant Risk Genes Uncovered from GWAS Statistical Noise
Correia, Catarina; Diekmann, Yoan; Vicente, Astrid; Pereira-Leal, JoséHundreds of genetic variants have been associated to common diseases through genome-wide association studies (GWAS), yet there are limits to current approaches in detecting true small effect risk variants against a background of false positive findings. Here we addressed the missing heritability problem, aiming to test whether there are indeed risk variants within GWAS statistical noise and to develop a systema...